Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912834433> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2912834433 abstract "In the mammalian central nervous system, gliogenesis and neurogenesis constitutively occurs in the subventricular zone (SVZ) and the hippocampus albeit on a much lower scale in comparison to the other organs. In response to stroke and presumably as an endogenous mechanism of brain self repair, the neural precursors located in the SVZ and the hippocampus are induced to proliferate and migrate towards stroke-damaged tissue. This innate neural reaction in adult brain may represent a mechanism of neuroplasticity and structural remodeling that leads to functional recovery. The rodent animal model of ischemic stroke (IS) showed a clear and pronounced neurogenesis and gliogenesis. However, to date little is known about this innate response in human and nonhuman primates to IS. We have developed a nonhuman primate model of IS with well-defined anatomical infarct lesions and motor behavioral deficit. After a small craniotomy, the dura was opened and with microsurgical technique and the M3 segment of the middle cerebral artery was occluded for 90 minutes followed by reperfusion. Animals with IS showed significant (p<0.005) motor deficit in right hand. To label endogenous neural precursors undergoing cell proliferation in vivo we injected all animals with the S-phase marker 5-bromo-2-deoxyuridine (BrdU). Postmortem analysis demonstrated significant increase of GFAP+ astrocytes (P<0.0001) in the infarct area. These astrocytes exhibited unique re-organization around the infarct zone and expressed various types of morphologies and phenotypes. Less than 1% incorporated BrdU. Sixty-five % of astrocytes with elongated processes oriented toward the IS co-expressed vimentin while tissue from control animals expressed no vimentin. Approximately 35% of astrocytes co-expressed Sox-2, while control animals showed about 4% in the same area of the cortex. Both vimentin and Sox-2 are markers for neural stem cells. These data suggests that astrocytes may be more heterogeneous than previously thought and may undertake various roles in response to IS. A subpopulation of astrocytes may be reprogrammed to an early developmental stage under IS conditions to promote tissue repair and homeostasis." @default.
- W2912834433 created "2019-02-21" @default.
- W2912834433 creator A5008597630 @default.
- W2912834433 creator A5058129833 @default.
- W2912834433 creator A5079251202 @default.
- W2912834433 date "2019-02-01" @default.
- W2912834433 modified "2023-09-25" @default.
- W2912834433 title "Abstract WP348: Astrocyte Reaction After Ischemic Stroke in Nonhuman Primate" @default.
- W2912834433 doi "https://doi.org/10.1161/str.50.suppl_1.wp348" @default.
- W2912834433 hasPublicationYear "2019" @default.
- W2912834433 type Work @default.
- W2912834433 sameAs 2912834433 @default.
- W2912834433 citedByCount "0" @default.
- W2912834433 crossrefType "journal-article" @default.
- W2912834433 hasAuthorship W2912834433A5008597630 @default.
- W2912834433 hasAuthorship W2912834433A5058129833 @default.
- W2912834433 hasAuthorship W2912834433A5079251202 @default.
- W2912834433 hasConcept C127413603 @default.
- W2912834433 hasConcept C136834591 @default.
- W2912834433 hasConcept C169760540 @default.
- W2912834433 hasConcept C2776361831 @default.
- W2912834433 hasConcept C2777542381 @default.
- W2912834433 hasConcept C2777542384 @default.
- W2912834433 hasConcept C2778818304 @default.
- W2912834433 hasConcept C2780645631 @default.
- W2912834433 hasConcept C2781161787 @default.
- W2912834433 hasConcept C28328180 @default.
- W2912834433 hasConcept C4746552 @default.
- W2912834433 hasConcept C47611674 @default.
- W2912834433 hasConcept C48261664 @default.
- W2912834433 hasConcept C529278444 @default.
- W2912834433 hasConcept C71924100 @default.
- W2912834433 hasConcept C78519656 @default.
- W2912834433 hasConcept C86803240 @default.
- W2912834433 hasConcept C95444343 @default.
- W2912834433 hasConceptScore W2912834433C127413603 @default.
- W2912834433 hasConceptScore W2912834433C136834591 @default.
- W2912834433 hasConceptScore W2912834433C169760540 @default.
- W2912834433 hasConceptScore W2912834433C2776361831 @default.
- W2912834433 hasConceptScore W2912834433C2777542381 @default.
- W2912834433 hasConceptScore W2912834433C2777542384 @default.
- W2912834433 hasConceptScore W2912834433C2778818304 @default.
- W2912834433 hasConceptScore W2912834433C2780645631 @default.
- W2912834433 hasConceptScore W2912834433C2781161787 @default.
- W2912834433 hasConceptScore W2912834433C28328180 @default.
- W2912834433 hasConceptScore W2912834433C4746552 @default.
- W2912834433 hasConceptScore W2912834433C47611674 @default.
- W2912834433 hasConceptScore W2912834433C48261664 @default.
- W2912834433 hasConceptScore W2912834433C529278444 @default.
- W2912834433 hasConceptScore W2912834433C71924100 @default.
- W2912834433 hasConceptScore W2912834433C78519656 @default.
- W2912834433 hasConceptScore W2912834433C86803240 @default.
- W2912834433 hasConceptScore W2912834433C95444343 @default.
- W2912834433 hasIssue "Suppl_1" @default.
- W2912834433 hasLocation W29128344331 @default.
- W2912834433 hasOpenAccess W2912834433 @default.
- W2912834433 hasPrimaryLocation W29128344331 @default.
- W2912834433 hasRelatedWork W1997026155 @default.
- W2912834433 hasRelatedWork W2035058003 @default.
- W2912834433 hasRelatedWork W2105086774 @default.
- W2912834433 hasRelatedWork W2135046848 @default.
- W2912834433 hasRelatedWork W2181024189 @default.
- W2912834433 hasRelatedWork W2609860343 @default.
- W2912834433 hasRelatedWork W2795670318 @default.
- W2912834433 hasRelatedWork W2912834433 @default.
- W2912834433 hasRelatedWork W2948457966 @default.
- W2912834433 hasRelatedWork W3034973246 @default.
- W2912834433 hasVolume "50" @default.
- W2912834433 isParatext "false" @default.
- W2912834433 isRetracted "false" @default.
- W2912834433 magId "2912834433" @default.
- W2912834433 workType "article" @default.