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- W2912841818 abstract "Significance Loss of insulin receptors in the brain causes metabolic and behavioral abnormalities whereas loss of IGF-1 receptors in the brain leads to a developmental defect in the brain and periphery. However, less is known about the impact of brain insulin and IGF-1 receptor (IR/IGF1R) loss in adult mice, especially in higher neural processing regions. Here, we show that loss of IR/IGF1R in the hippocampus and central amygdala of adult mice results in decrease in glutamate receptors, accompanied by glucose intolerance, anxiety-like behavior, and impaired cognition. In addition, we identify an insulin/IGF-1 signaling-dependent neural circuit originating from the central amygdala, which regulates interscapular brown fat activity and thermogenesis. Thus, brain insulin/IGF-1 signaling is important for higher neural processing and systemic metabolism." @default.
- W2912841818 created "2019-02-21" @default.
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- W2912841818 date "2019-02-14" @default.
- W2912841818 modified "2023-10-17" @default.
- W2912841818 title "Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior" @default.
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- W2912841818 doi "https://doi.org/10.1073/pnas.1817391116" @default.
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