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- W2912841959 abstract "Drug-induced colony-stimulating factor 1 receptor (CSF1R) blockage is now a commonly used tool to cause reversible microglia depletion in mice. However, microglial depletion is not complete with a remaining fraction of approximately 5% of the original microglia. In order to characterize this remarkably stable portion of the microglia we used fluorescent cytometry (FACS) and mass cytometry (CyTOF) in PLX3397-treated mice and found that the microglia in those animals represents a unique population different from normal microglia and bearing a lot of features usually associated with a pro-inflammatory and activated phenotype. In addition, behavioral analyses revealed subtle changes that may be interpreted as sickness behavior. Treated with a peripheral injection of LPS, (0.8 mg/kg ip) remaining microglia of depleted animals showed a much stronger inflammatory response and such-treated animals displayed a more pronounced behavioral response to LPS than control animals. Finally, we injected animals that were just at the beginning of their 1 week PLX3397 treatment with LPS and surprisingly found the resulting neuroinflammatory response to be capable of blocking the PLX-induced microglia depletion and inducing a microglial phenotype that was different from control, only LPS-treated and only PLX-treated microglia. Our observation is consistent with the emerging science that microglia do have different roles and phenotypes depending on cellular environment and disease pathology and remains to be studied in greater detail." @default.
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- W2912841959 date "2019-02-01" @default.
- W2912841959 modified "2023-09-27" @default.
- W2912841959 title "Abstract # 3176 Systemic lipopolysaccharide (LPS) prevents microglial loss after CSF1 receptor blockade" @default.
- W2912841959 doi "https://doi.org/10.1016/j.bbi.2018.11.287" @default.
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