Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912842263> ?p ?o ?g. }
- W2912842263 endingPage "63" @default.
- W2912842263 startingPage "56" @default.
- W2912842263 abstract "Bruton tyrosine kinase signaling (BTK) is critical step for B-cell development and immunoglobulin synthesis. Ibrutinib is an orally bioavailable bruton tyrosine kinase inhibitor (BTKi) and forms an irreversible covalent bound to BTK at the Cysteine-481 residue. Ibrutinib has been approved by FDA for the treatment of mantle cell lymphoma, chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, marginal zone lymphoma and chronic graft-versus-host disease in allogeneic stem cell transplantation. Ibrutinib is generally well tolerated drug with rapid and durable responses but has some side events. The most common side effects are diarrhea, upper respiratory tract infection, bleeding, fatigue and cardiac side effects. These events are generally mild (grade I-II). However atrial fibrillation (AF) and bleeding are important and may be grade III or higher side effects require strict monitoring. Here side effects of ibrutinib have been summarized and important considerations in the management of these adverse events have been reviewed." @default.
- W2912842263 created "2019-02-21" @default.
- W2912842263 creator A5005309444 @default.
- W2912842263 date "2019-04-01" @default.
- W2912842263 modified "2023-09-30" @default.
- W2912842263 title "Management of adverse effects/toxicity of ibrutinib" @default.
- W2912842263 cites W1829587101 @default.
- W2912842263 cites W1874872148 @default.
- W2912842263 cites W1891620832 @default.
- W2912842263 cites W1935657689 @default.
- W2912842263 cites W1971798684 @default.
- W2912842263 cites W1976225087 @default.
- W2912842263 cites W1979834961 @default.
- W2912842263 cites W1982041993 @default.
- W2912842263 cites W1986924929 @default.
- W2912842263 cites W2012594643 @default.
- W2912842263 cites W2023976667 @default.
- W2912842263 cites W2025703773 @default.
- W2912842263 cites W2025707347 @default.
- W2912842263 cites W2026310926 @default.
- W2912842263 cites W2054220445 @default.
- W2912842263 cites W2071549499 @default.
- W2912842263 cites W2075875145 @default.
- W2912842263 cites W2083605437 @default.
- W2912842263 cites W2108206643 @default.
- W2912842263 cites W2115086589 @default.
- W2912842263 cites W2133192145 @default.
- W2912842263 cites W2140395974 @default.
- W2912842263 cites W2143032169 @default.
- W2912842263 cites W2143766748 @default.
- W2912842263 cites W2150487985 @default.
- W2912842263 cites W2154066874 @default.
- W2912842263 cites W2163690533 @default.
- W2912842263 cites W2182998787 @default.
- W2912842263 cites W2187899653 @default.
- W2912842263 cites W2190884983 @default.
- W2912842263 cites W2191219754 @default.
- W2912842263 cites W2233614027 @default.
- W2912842263 cites W2260369425 @default.
- W2912842263 cites W2272026584 @default.
- W2912842263 cites W2302072645 @default.
- W2912842263 cites W2307952155 @default.
- W2912842263 cites W2323490326 @default.
- W2912842263 cites W2399623634 @default.
- W2912842263 cites W2421821505 @default.
- W2912842263 cites W2464293395 @default.
- W2912842263 cites W2474112571 @default.
- W2912842263 cites W2506185426 @default.
- W2912842263 cites W2508765370 @default.
- W2912842263 cites W2514172728 @default.
- W2912842263 cites W2516544744 @default.
- W2912842263 cites W2516709103 @default.
- W2912842263 cites W2522309823 @default.
- W2912842263 cites W2532772806 @default.
- W2912842263 cites W2550091596 @default.
- W2912842263 cites W2557801192 @default.
- W2912842263 cites W2568981975 @default.
- W2912842263 cites W2580095139 @default.
- W2912842263 cites W2580500393 @default.
- W2912842263 cites W2587059675 @default.
- W2912842263 cites W2587684973 @default.
- W2912842263 cites W2589157782 @default.
- W2912842263 cites W2604832096 @default.
- W2912842263 cites W2606995900 @default.
- W2912842263 cites W2613723809 @default.
- W2912842263 cites W2739393823 @default.
- W2912842263 cites W2743273314 @default.
- W2912842263 cites W2754850852 @default.
- W2912842263 cites W2755262640 @default.
- W2912842263 cites W2792986018 @default.
- W2912842263 cites W2793645303 @default.
- W2912842263 cites W2802430440 @default.
- W2912842263 cites W2885033960 @default.
- W2912842263 cites W3004050106 @default.
- W2912842263 doi "https://doi.org/10.1016/j.critrevonc.2019.02.001" @default.
- W2912842263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30878129" @default.
- W2912842263 hasPublicationYear "2019" @default.
- W2912842263 type Work @default.
- W2912842263 sameAs 2912842263 @default.
- W2912842263 citedByCount "80" @default.
- W2912842263 countsByYear W29128422632019 @default.
- W2912842263 countsByYear W29128422632020 @default.
- W2912842263 countsByYear W29128422632021 @default.
- W2912842263 countsByYear W29128422632022 @default.
- W2912842263 countsByYear W29128422632023 @default.
- W2912842263 crossrefType "journal-article" @default.
- W2912842263 hasAuthorship W2912842263A5005309444 @default.
- W2912842263 hasConcept C126322002 @default.
- W2912842263 hasConcept C197934379 @default.
- W2912842263 hasConcept C2777938653 @default.
- W2912842263 hasConcept C2778461978 @default.
- W2912842263 hasConcept C2779878957 @default.
- W2912842263 hasConcept C29730261 @default.
- W2912842263 hasConcept C71924100 @default.
- W2912842263 hasConcept C98274493 @default.
- W2912842263 hasConceptScore W2912842263C126322002 @default.
- W2912842263 hasConceptScore W2912842263C197934379 @default.
- W2912842263 hasConceptScore W2912842263C2777938653 @default.