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- W2912843916 abstract "Introduction: Ticagrelor, a P2Y12 antagonist approved for the treatment of coronary disease, also blocks adenosine reuptake, and potentiation of adenosine actions may contribute to its unique pleiotropic beneficial effects (improved cardiovascular mortality) and side effects (dyspnea, asymptomatic ventricular pauses). Hypothesis: Because the clinical relevance of this effect is unclear, we used the isolated forearm model to test the hypothesis that ticagrelor blocks adenosine reuptake, taking advantage of the fact that the vascular wall expresses high affinity nucleoside transporters that provide a barrier to transfer of adenosine from the intravascular compartment to the underlying interstitium. Methods: We infused intrabrachial adenosine 0.125 mg/min and measured vasodilation (forearm blood flow, FBF) and dialysate concentrations of adenosine ([Ado]) from a microdialysis probe inserted in the underlying muscle, in 3 groups of normal subjects before and 2 hrs after oral administration of placebo, the ade..." @default.
- W2912843916 created "2019-02-21" @default.
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- W2912843916 date "2017-11-14" @default.
- W2912843916 modified "2023-09-23" @default.
- W2912843916 title "Abstract 20532: Ticagrelor and Adenosine Reuptake Blockade" @default.
- W2912843916 hasPublicationYear "2017" @default.
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