FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912843955> ?p ?o ?g. }

• W2912843955 endingPage "185" @default.
• W2912843955 startingPage "177" @default.
• W2912843955 abstract "Transcriptomic profiling has enabled the neater genomic characterization of several cancers, among them colorectal cancer (CRC), through the derivation of genes with enhanced causal role and informative gene sets. However, the identification of small-sized gene signatures, which can serve as potential biomarkers in CRC, remains challenging, mainly due to the great genetic heterogeneity of the disease.We developed and exploited an analytical framework for the integrative analysis of CRC datasets, encompassing transcriptomic data and positron emission tomography (PET) measurements. Profiling data comprised two microarray datasets, pertaining biopsy specimen from 30 untreated patients with primary CRC, coupled by their F-18-Fluorodeoxyglucose (FDG) PET values, using tracer kinetic analysis measurements. The computational framework incorporates algorithms for semantic processing, multivariate analysis, data mining and dimensionality reduction.Transcriptomic and PET data feature sets, were evaluated for their discrimination performance between primary colorectal adenocarcinomas and adjacent normal mucosa. A composite signature was derived, pertaining 12 features: 7 genes and 5 PET variables. This compact signature manifests superior performance in classification accuracy, through the integration of gene expression and PET data.This work represents an effort for the integrative, multilayered, signature-oriented analysis of CRC, in the context of radio-genomics, inferring a composite signature with promising results for patient stratification." @default.
• W2912843955 created "2019-02-21" @default.
• W2912843955 creator A5008622761 @default.
• W2912843955 creator A5017363870 @default.
• W2912843955 creator A5023705567 @default.
• W2912843955 creator A5044583234 @default.
• W2912843955 creator A5057297609 @default.
• W2912843955 creator A5059335751 @default.
• W2912843955 creator A5060233539 @default.
• W2912843955 creator A5066834291 @default.
• W2912843955 creator A5067189264 @default.
• W2912843955 creator A5073690629 @default.
• W2912843955 creator A5076324907 @default.
• W2912843955 creator A5078087307 @default.
• W2912843955 creator A5089419287 @default.
• W2912843955 date "2019-01-01" @default.
• W2912843955 modified "2023-10-18" @default.
• W2912843955 title "Radiogenomic Analysis of F-18-Fluorodeoxyglucose Positron Emission Tomography and Gene Expression Data Elucidates the Epidemiological Complexity of Colorectal Cancer Landscape" @default.
• W2912843955 cites W1580554432 @default.
• W2912843955 cites W1934094702 @default.
• W2912843955 cites W1956377522 @default.
• W2912843955 cites W1973094248 @default.
• W2912843955 cites W1973728613 @default.
• W2912843955 cites W2052543023 @default.
• W2912843955 cites W2056633943 @default.
• W2912843955 cites W2056822151 @default.
• W2912843955 cites W2057897100 @default.
• W2912843955 cites W2073048468 @default.
• W2912843955 cites W2086780955 @default.
• W2912843955 cites W2086810487 @default.
• W2912843955 cites W2088878023 @default.
• W2912843955 cites W2093573845 @default.
• W2912843955 cites W2094200791 @default.
• W2912843955 cites W2097360283 @default.
• W2912843955 cites W2117692326 @default.
• W2912843955 cites W2131640299 @default.
• W2912843955 cites W2135827569 @default.
• W2912843955 cites W2146512944 @default.
• W2912843955 cites W2156149964 @default.
• W2912843955 cites W2230320310 @default.
• W2912843955 cites W2262414037 @default.
• W2912843955 cites W2402482005 @default.
• W2912843955 cites W2406250479 @default.
• W2912843955 cites W2527825216 @default.
• W2912843955 cites W2568051433 @default.
• W2912843955 cites W2569086487 @default.
• W2912843955 cites W2617184869 @default.
• W2912843955 cites W2749296525 @default.
• W2912843955 cites W2749613778 @default.
• W2912843955 cites W2782992910 @default.
• W2912843955 cites W2792009377 @default.
• W2912843955 cites W4211001330 @default.
• W2912843955 doi "https://doi.org/10.1016/j.csbj.2019.01.007" @default.
• W2912843955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6374701" @default.
• W2912843955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30809322" @default.
• W2912843955 hasPublicationYear "2019" @default.
• W2912843955 type Work @default.
• W2912843955 sameAs 2912843955 @default.
• W2912843955 citedByCount "40" @default.
• W2912843955 countsByYear W29128439552020 @default.
• W2912843955 countsByYear W29128439552021 @default.
• W2912843955 countsByYear W29128439552022 @default.
• W2912843955 countsByYear W29128439552023 @default.
• W2912843955 crossrefType "journal-article" @default.
• W2912843955 hasAuthorship W2912843955A5008622761 @default.
• W2912843955 hasAuthorship W2912843955A5017363870 @default.
• W2912843955 hasAuthorship W2912843955A5023705567 @default.
• W2912843955 hasAuthorship W2912843955A5044583234 @default.
• W2912843955 hasAuthorship W2912843955A5057297609 @default.
• W2912843955 hasAuthorship W2912843955A5059335751 @default.
• W2912843955 hasAuthorship W2912843955A5060233539 @default.
• W2912843955 hasAuthorship W2912843955A5066834291 @default.
• W2912843955 hasAuthorship W2912843955A5067189264 @default.
• W2912843955 hasAuthorship W2912843955A5073690629 @default.
• W2912843955 hasAuthorship W2912843955A5076324907 @default.
• W2912843955 hasAuthorship W2912843955A5078087307 @default.
• W2912843955 hasAuthorship W2912843955A5089419287 @default.
• W2912843955 hasBestOaLocation W29128439551 @default.
• W2912843955 hasConcept C104317684 @default.
• W2912843955 hasConcept C121608353 @default.
• W2912843955 hasConcept C150194340 @default.
• W2912843955 hasConcept C151730666 @default.
• W2912843955 hasConcept C154945302 @default.
• W2912843955 hasConcept C18431079 @default.
• W2912843955 hasConcept C2775842073 @default.
• W2912843955 hasConcept C2779343474 @default.
• W2912843955 hasConcept C2779733811 @default.
• W2912843955 hasConcept C2989005 @default.
• W2912843955 hasConcept C41008148 @default.
• W2912843955 hasConcept C526805850 @default.
• W2912843955 hasConcept C54355233 @default.
• W2912843955 hasConcept C60644358 @default.
• W2912843955 hasConcept C70518039 @default.
• W2912843955 hasConcept C70721500 @default.
• W2912843955 hasConcept C71924100 @default.
• W2912843955 hasConcept C86803240 @default.
• W2912843955 hasConceptScore W2912843955C104317684 @default.
• W2912843955 hasConceptScore W2912843955C121608353 @default.

• next