FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912848079> ?p ?o ?g. }

• W2912848079 abstract "The role of mean platelet volume (MPV) as a predictor of outcomes in various cancer entities including colorectal cancer (CRC) has already been analyzed. However, data on the prognostic and predictive value of MPV in CRC over multiple lines of systemic therapy are missing.In this retrospective single-center cohort study, 690 patients with UICC stage II, III or IV CRC receiving adjuvant and/or palliative chemotherapy were included. Primary endpoints in the adjuvant, palliative and best supportive care (BSC) setting were 3-year recurrence-free survival (RFS), 6-months progression-free survival (PFS), and 6-months overall survival (OS), respectively. Kaplan-Meier estimators, log-rank tests, and uni- and multivariable Cox models were used to analyze RFS, PFS and OS. A cut-off defining patients with low MPV was chosen empirically at the 25th percentile of the MPV distribution in the respective treatment setting.Three-year RFS was 76%. Median 6-month PFS estimates in 1st, 2nd and 3rd line therapy were 59, 37 and 27%, respectively. Median 6-month OS in BSC was 31%. Small platelets as indicated by low MPV did not predict for shorter RFS. In the first 3 palliative treatment lines a consistent association between low MPV and decreased 6-month PFS was not observed. In the BSC setting, patients with low MPV had numerically but not significantly shorter OS. Higher MPV levels did not consistently predict for ORR or DCR across the first 3 palliative treatment lines.Small platelets are not predicting CRC outcomes, and thus are hardly useful for influencing clinical decision making." @default.
• W2912848079 created "2019-02-21" @default.
• W2912848079 creator A5005593510 @default.
• W2912848079 creator A5006483196 @default.
• W2912848079 creator A5012484710 @default.
• W2912848079 creator A5012530512 @default.
• W2912848079 creator A5024367774 @default.
• W2912848079 creator A5032685387 @default.
• W2912848079 creator A5040602619 @default.
• W2912848079 creator A5047374036 @default.
• W2912848079 creator A5052263181 @default.
• W2912848079 creator A5057847281 @default.
• W2912848079 creator A5091130407 @default.
• W2912848079 date "2019-01-22" @default.
• W2912848079 modified "2023-09-23" @default.
• W2912848079 title "Critical evaluation of platelet size as a prognostic biomarker in colorectal cancer across multiple treatment settings: a retrospective cohort study" @default.
• W2912848079 cites W1842995251 @default.
• W2912848079 cites W1975741271 @default.
• W2912848079 cites W1981019645 @default.
• W2912848079 cites W2004752288 @default.
• W2912848079 cites W2024671872 @default.
• W2912848079 cites W2049681458 @default.
• W2912848079 cites W2056055025 @default.
• W2912848079 cites W2072671591 @default.
• W2912848079 cites W2075324375 @default.
• W2912848079 cites W2096378972 @default.
• W2912848079 cites W2118768129 @default.
• W2912848079 cites W2123105952 @default.
• W2912848079 cites W2146832883 @default.
• W2912848079 cites W2159045567 @default.
• W2912848079 cites W2162200548 @default.
• W2912848079 cites W2163147899 @default.
• W2912848079 cites W2174295196 @default.
• W2912848079 cites W2313487206 @default.
• W2912848079 cites W2348480799 @default.
• W2912848079 cites W2507608866 @default.
• W2912848079 cites W2531121024 @default.
• W2912848079 cites W2570618306 @default.
• W2912848079 cites W2733488771 @default.
• W2912848079 cites W2735121685 @default.
• W2912848079 cites W2735666689 @default.
• W2912848079 cites W2747763184 @default.
• W2912848079 cites W2763092712 @default.
• W2912848079 cites W2797421660 @default.
• W2912848079 doi "https://doi.org/10.1007/s12094-019-02037-7" @default.
• W2912848079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30671731" @default.
• W2912848079 hasPublicationYear "2019" @default.
• W2912848079 type Work @default.
• W2912848079 sameAs 2912848079 @default.
• W2912848079 citedByCount "3" @default.
• W2912848079 countsByYear W29128480792019 @default.
• W2912848079 countsByYear W29128480792020 @default.
• W2912848079 crossrefType "journal-article" @default.
• W2912848079 hasAuthorship W2912848079A5005593510 @default.
• W2912848079 hasAuthorship W2912848079A5006483196 @default.
• W2912848079 hasAuthorship W2912848079A5012484710 @default.
• W2912848079 hasAuthorship W2912848079A5012530512 @default.
• W2912848079 hasAuthorship W2912848079A5024367774 @default.
• W2912848079 hasAuthorship W2912848079A5032685387 @default.
• W2912848079 hasAuthorship W2912848079A5040602619 @default.
• W2912848079 hasAuthorship W2912848079A5047374036 @default.
• W2912848079 hasAuthorship W2912848079A5052263181 @default.
• W2912848079 hasAuthorship W2912848079A5057847281 @default.
• W2912848079 hasAuthorship W2912848079A5091130407 @default.
• W2912848079 hasBestOaLocation W29128480791 @default.
• W2912848079 hasConcept C121608353 @default.
• W2912848079 hasConcept C126322002 @default.
• W2912848079 hasConcept C143998085 @default.
• W2912848079 hasConcept C159110408 @default.
• W2912848079 hasConcept C167135981 @default.
• W2912848079 hasConcept C190481736 @default.
• W2912848079 hasConcept C2994186709 @default.
• W2912848079 hasConcept C50382708 @default.
• W2912848079 hasConcept C526805850 @default.
• W2912848079 hasConcept C71924100 @default.
• W2912848079 hasConcept C72563966 @default.
• W2912848079 hasConcept C89560881 @default.
• W2912848079 hasConceptScore W2912848079C121608353 @default.
• W2912848079 hasConceptScore W2912848079C126322002 @default.
• W2912848079 hasConceptScore W2912848079C143998085 @default.
• W2912848079 hasConceptScore W2912848079C159110408 @default.
• W2912848079 hasConceptScore W2912848079C167135981 @default.
• W2912848079 hasConceptScore W2912848079C190481736 @default.
• W2912848079 hasConceptScore W2912848079C2994186709 @default.
• W2912848079 hasConceptScore W2912848079C50382708 @default.
• W2912848079 hasConceptScore W2912848079C526805850 @default.
• W2912848079 hasConceptScore W2912848079C71924100 @default.
• W2912848079 hasConceptScore W2912848079C72563966 @default.
• W2912848079 hasConceptScore W2912848079C89560881 @default.
• W2912848079 hasLocation W29128480791 @default.
• W2912848079 hasLocation W29128480792 @default.
• W2912848079 hasLocation W29128480793 @default.
• W2912848079 hasOpenAccess W2912848079 @default.
• W2912848079 hasPrimaryLocation W29128480791 @default.
• W2912848079 hasRelatedWork W2020048154 @default.
• W2912848079 hasRelatedWork W2024035201 @default.
• W2912848079 hasRelatedWork W2148994831 @default.
• W2912848079 hasRelatedWork W2154326194 @default.
• W2912848079 hasRelatedWork W2349470571 @default.
• W2912848079 hasRelatedWork W2368297896 @default.

• next