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- W2912851627 abstract "Red blood cells (RBCs) have remarkable mechanical properties that are major determinants of blood flow. This is made possible by the unique structure of the erythrocytes. The lipid membrane accounts for the bending rigidity of RBCs whereas the membrane skeleton, built mainly of a spectrin dimer network sparsely anchored to the lipid bilayer, regulates the shear elasticity.[1] Deformation of RBC is a key property to ensure efficient passage through the microcirculation. A number of diseases such as diabetes may cause changes in the RBC's deformability and the physical properties of the erythrocyte plasma membrane due to oxidative stress.[2] To reduce the complexity of the system, model membranes and lipid monolayers have been used to determine membrane properties.[3] We investigate the microdomain structure of synthetic lipid monolayers mimicking the composition of the inner or outer leaflet of erythrocyte plasma membranes by means of the Langmuir trough technique coupled with fluorescence microscopy, gracing incidence X-ray diffraction (GIXD) and X-ray reflectivity (XRR) to study domain structures. Surface relaxation (dilational rheology) is used to quantify the dynamic interfacial rheological properties of the lipid film and Molecular Dynamics (MD) simulations reveal details in monolayer organization at molecular length scales. In particular, we investigate the effect of oxidation of key membrane constituents to clarify the role of oxidative stress on the plasma membrane organisation and physical properties. We show that replacement of cholesterol by 7-ketocholesterol as main oxidation product leads to significant stiffening of the monolayer at surface pressures above 20 mN/m, in the range of the bilayer equivalence surface pressure (π ≈ 30 mN/m). Fluorescence imaging was used to reveal crystallite-like microdomain structures of the monomolecular layers containing 7-ketocholesterol whereas the monolayer with non-oxidized cholesterol features more circular domains." @default.
- W2912851627 created "2019-02-21" @default.
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- W2912851627 date "2019-02-01" @default.
- W2912851627 modified "2023-09-30" @default.
- W2912851627 title "Microdomain Structure and Mechanical Properties of Lipid Monolayers Mimicking Red Blood Cell Membranes Under Oxidative Stress" @default.
- W2912851627 doi "https://doi.org/10.1016/j.bpj.2018.11.914" @default.
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