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• W2912852543 endingPage "7811" @default.
• W2912852543 startingPage "7800" @default.
• W2912852543 abstract "The combination therapy of photothermal therapy and chemotherapy as a promising strategy has drawn extensive attention by overcoming the limitations of conventional treatments in tumor therapy. Gold nanorods-based nanoplatforms were herein designed by integrating doxorubicin (DOX)- and polydopamine-coated gold nanorods (GNRs@PDA) for tumor metastasis inhibition and multifunctional drug delivery. The GNRs@PDA–poly(ethylene glycol) (PEG)–DOX nanocomplex showed robust stability and excellent near-infrared (NIR) photothermal conversion efficiency under laser irradiation. The release of loaded DOX from GNRs@PDA–PEG–DOX nanocomposites was improved in tumor microenvironments. Furthermore, the PDA-functionalized GNR nanocomposites were expected to be potential photoacoustic imaging agents for imaging-guided tumor therapy. Upon NIR laser irradiation, the efficiency of tumor inhibition of GNRs@PDA–PEG–DOX is greater than that of the other group in vitro and in vivo, which was confirmed by immunohistochemistry staining, demonstrating a promising strategy for suppression of tumor metastasis and low long-term systemic toxicity. These results illustrated a promising strategy of tailor-made GNRs@PDA–PEG–DOX nanoplatforms for ablation of tumor and suppression of tumor metastasis in clinical application." @default.
• W2912852543 created "2019-02-21" @default.
• W2912852543 creator A5051862477 @default.
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• W2912852543 date "2019-02-05" @default.
• W2912852543 modified "2023-10-12" @default.
• W2912852543 title "Gold Nanorods-Based Smart Nanoplatforms for Synergic Thermotherapy and Chemotherapy of Tumor Metastasis" @default.
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• W2912852543 doi "https://doi.org/10.1021/acsami.8b21784" @default.
• W2912852543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30720270" @default.
• W2912852543 hasPublicationYear "2019" @default.
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