Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912853410> ?p ?o ?g. }
- W2912853410 endingPage "e12987" @default.
- W2912853410 startingPage "e12987" @default.
- W2912853410 abstract "Testicular torsion-related oxidative stress causes a sequential chain of DNA damage, lipid peroxidation and cell death that leads to the derangement in the sperm functions and infertility. Capsaicin that has been applied for pain relief and cancer prevention possesses antioxidant properties which can be exploited to confer cell survival under ischaemic testis damage. Wistar male rats weighing 150-200 g were randomly divided into four groups: (i) sham group (all procedures except torsion of testis), (ii) ischaemia group (TT group), (iii) three TT groups treated with different dose of capsaicin (TT + different doses of Cap) and (iv) three control groups treated with different doses of capsaicin (100, 500 and 1000 ug/ml). Capsaicin administration significantly decreased the expression of pro-apoptotic factors and increased the expression of anti-apoptotic factors. Likewise, the expression of FOXO1 is significantly increased by higher doses of the capsaicin. Histological assessment by H&E and TUNEL method also exhibited an improved testicular morphology and decreased apoptosis in testes. These results suggested clinical potential for capsaicin in treatment of testicular torsion by targeting FOXO1 and apoptotic pathways." @default.
- W2912853410 created "2019-02-21" @default.
- W2912853410 creator A5005660257 @default.
- W2912853410 creator A5024079750 @default.
- W2912853410 creator A5057925669 @default.
- W2912853410 creator A5068919836 @default.
- W2912853410 creator A5087842764 @default.
- W2912853410 date "2018-02-07" @default.
- W2912853410 modified "2023-10-18" @default.
- W2912853410 title "FOXO1 targeting by capsaicin reduces tissue damage after testicular torsion" @default.
- W2912853410 cites W1579377888 @default.
- W2912853410 cites W1947394795 @default.
- W2912853410 cites W1970321753 @default.
- W2912853410 cites W1977180999 @default.
- W2912853410 cites W1984336207 @default.
- W2912853410 cites W1997920181 @default.
- W2912853410 cites W2012009655 @default.
- W2912853410 cites W2014633578 @default.
- W2912853410 cites W2039201086 @default.
- W2912853410 cites W2047865631 @default.
- W2912853410 cites W2057053287 @default.
- W2912853410 cites W2057217856 @default.
- W2912853410 cites W2064800884 @default.
- W2912853410 cites W2066076670 @default.
- W2912853410 cites W2070624095 @default.
- W2912853410 cites W2081317780 @default.
- W2912853410 cites W2096026962 @default.
- W2912853410 cites W2099731559 @default.
- W2912853410 cites W2103841082 @default.
- W2912853410 cites W2106220400 @default.
- W2912853410 cites W2108536849 @default.
- W2912853410 cites W2110899205 @default.
- W2912853410 cites W2118991584 @default.
- W2912853410 cites W2121858345 @default.
- W2912853410 cites W2137208217 @default.
- W2912853410 cites W2142078834 @default.
- W2912853410 cites W2152038317 @default.
- W2912853410 cites W2165507439 @default.
- W2912853410 cites W2166527974 @default.
- W2912853410 cites W2167985455 @default.
- W2912853410 cites W2168013278 @default.
- W2912853410 cites W2187580567 @default.
- W2912853410 cites W2291745239 @default.
- W2912853410 cites W2343155009 @default.
- W2912853410 cites W2345981739 @default.
- W2912853410 cites W2397726802 @default.
- W2912853410 cites W2464822424 @default.
- W2912853410 cites W2496984765 @default.
- W2912853410 cites W2498461908 @default.
- W2912853410 cites W2519440804 @default.
- W2912853410 cites W2537688488 @default.
- W2912853410 cites W2559267327 @default.
- W2912853410 cites W2603130142 @default.
- W2912853410 cites W2607741371 @default.
- W2912853410 cites W2611610652 @default.
- W2912853410 cites W2752013440 @default.
- W2912853410 cites W2767205284 @default.
- W2912853410 doi "https://doi.org/10.1111/and.12987" @default.
- W2912853410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29411905" @default.
- W2912853410 hasPublicationYear "2018" @default.
- W2912853410 type Work @default.
- W2912853410 sameAs 2912853410 @default.
- W2912853410 citedByCount "6" @default.
- W2912853410 countsByYear W29128534102018 @default.
- W2912853410 countsByYear W29128534102019 @default.
- W2912853410 countsByYear W29128534102021 @default.
- W2912853410 countsByYear W29128534102022 @default.
- W2912853410 crossrefType "journal-article" @default.
- W2912853410 hasAuthorship W2912853410A5005660257 @default.
- W2912853410 hasAuthorship W2912853410A5024079750 @default.
- W2912853410 hasAuthorship W2912853410A5057925669 @default.
- W2912853410 hasAuthorship W2912853410A5068919836 @default.
- W2912853410 hasAuthorship W2912853410A5087842764 @default.
- W2912853410 hasBestOaLocation W29128534101 @default.
- W2912853410 hasConcept C126322002 @default.
- W2912853410 hasConcept C134018914 @default.
- W2912853410 hasConcept C141071460 @default.
- W2912853410 hasConcept C16685009 @default.
- W2912853410 hasConcept C170493617 @default.
- W2912853410 hasConcept C185592680 @default.
- W2912853410 hasConcept C190283241 @default.
- W2912853410 hasConcept C196795494 @default.
- W2912853410 hasConcept C204232928 @default.
- W2912853410 hasConcept C2776151105 @default.
- W2912853410 hasConcept C2777338322 @default.
- W2912853410 hasConcept C2777688143 @default.
- W2912853410 hasConcept C2779170295 @default.
- W2912853410 hasConcept C2779234561 @default.
- W2912853410 hasConcept C2780051329 @default.
- W2912853410 hasConcept C2780829032 @default.
- W2912853410 hasConcept C54355233 @default.
- W2912853410 hasConcept C55493867 @default.
- W2912853410 hasConcept C71924100 @default.
- W2912853410 hasConcept C86803240 @default.
- W2912853410 hasConcept C98274493 @default.
- W2912853410 hasConceptScore W2912853410C126322002 @default.
- W2912853410 hasConceptScore W2912853410C134018914 @default.
- W2912853410 hasConceptScore W2912853410C141071460 @default.