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- W2912853626 abstract "Abstract BACKGROUND Neuropeptides are regulators of critical life processes in insects and, due to their high specificity, represent potential targets in the development of greener insecticidal agents. Fundamental to this drive is understanding neuroendocrine pathways that control key physiological processes in pest insects and the screening of potential analogues. The current study investigated neuropeptide binding sites of kinin and CAPA (CAPA‐1) in the aphids Myzus persicae and Macrosiphum rosae and the effect of biostable analogues on aphid fitness under conditions of desiccation, starvation and thermal (cold) stress. RESULTS M. persicae and M. rosae displayed identical patterns of neuropeptide receptor mapping along the gut, with the gut musculature representing the main target for kinin and CAPA‐1 action. While kinin receptor binding was observed in the brain and VNC of M. persicae , this was not observed in M. rosae . Furthermore, no CAPA‐1 receptor binding was observed in the brain and VNC of either species. CAP2b/PK analogues (with CAPA receptor cross‐activity) were most effective in reducing aphid fitness under conditions of desiccation and starvation stress, particularly analogues 1895 ( 2Abf ‐ Suc ‐FGPRLa) and 2129 ( 2Abf ‐ Suc ‐ A TPRIa), which expedited aphid mortality. All analogues, with the exception of 2139‐Ac, were efficient at reducing aphid survival under cold stress, although were equivalent in the strength of their effect. CONCLUSION In demonstrating the effects of analogues belonging to the CAP2b neuropeptide family and key analogue structures that reduce aphid fitness under stress conditions, this research will feed into the development of second generation analogues and ultimately the development of neuropeptidomimetic‐based insecticidal agents. © 2019 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry." @default.
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- W2912853626 date "2019-03-21" @default.
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- W2912853626 title "Assessment of neuropeptide binding sites and the impact of biostable kinin and CAP2b analogue treatment on aphid (<scp><i>Myzus persicae</i></scp>and<i>Macrosiphum rosae</i>) stress tolerance" @default.
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- W2912853626 cites W1970793109 @default.
- W2912853626 cites W1972255915 @default.
- W2912853626 cites W1978203681 @default.
- W2912853626 cites W1985046771 @default.
- W2912853626 cites W1991840769 @default.
- W2912853626 cites W1996476683 @default.
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- W2912853626 doi "https://doi.org/10.1002/ps.5372" @default.
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