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- W2912856824 abstract "The long non‐coding RNA s (lnc RNA s) are known to transcriptionally regulate a wide spectrum of diseases. Here, we screened for potentially functional lnc RNA s in a mammary epithelial cell model of bovine mastitis by RNA ‐Seq technology and identified a class of previously undetected mastitis‐related lnc RNA s. A novel lnc RNA was widely expressed in a variety of bovine tissues with diverse relative abundance and had a relatively low expression in mammary tissue. Given its predicted target gene is TUBA1C , we name it lnc RNA ‐ TUB . We found a higher expression of lnc RNA ‐ TUB in mammary epithelial cells that received a proinflammatory stimulus compared to normal cells. Knockout of lnc RNA ‐ TUB by the CRISPR /Cas9 system revealed that it plays crucial roles in the morphological shape, proliferation, migration and β‐casein secretion of mammary epithelial cells. In addition, lnc RNA ‐ TUB mediates Escherichia coli ‐induced inflammatory factor secretion and Staphylococcus aureus adhesion to epithelial cells. Our results suggest that the lnc RNA s identified here function in bovine mastitis, and that lnc RNA ‐ TUB affects the basic biological characteristics and functions of bovine mammary epithelial cells in inflammatory conditions, providing valuable insights into the mechanisms of bovine mastitis." @default.
- W2912856824 created "2019-02-21" @default.
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- W2912856824 date "2019-03-12" @default.
- W2912856824 modified "2023-10-07" @default.
- W2912856824 title "A novel long non‐coding <scp>RNA</scp> regulates the immune response in <scp>MAC</scp>‐T cells and contributes to bovine mastitis" @default.
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- W2912856824 doi "https://doi.org/10.1111/febs.14783" @default.
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