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- W2912858066 abstract "Le dosage de l'histamine plasmatique chez l'homme permet de faire un diagnostic d'histaminolibération, d'élucider le mécanisme des réactions adverses aux médicaments, et d'identifier des situations cliniques en anesthésie et en chirurgie où un niveau pathologique d'histamine peut être atteint. Les titres normaux et pathologiques d'histamine plasmatique varient énormément dans la littérature. D'après plusieurs études, notamment une de 300 malades à Heidelberg (R.F.A.), une concentration d'histamine plasmatique supérieure à 1,0 ng · ml−1 peut être considérée comme pathologique chez l'homme (valeurs normales : 0 à 1,0 ng · ml−1). Les problèmes posés par le prélèvement du sang et la préparation du plasma sont présentés en détail. Toute critique de la méthode décrite doit tenir compte de notre expérience de 15 ans, de sa fiabilité dans des situations cliniques, de sa praticabilité, de son coût relativement peu élevé, ainsi que de la possibilité de travailler sans isotope radio-actif. Plasma histamine assay in man is indicated for the diagnosis of histamine release, as well as the elucidation of the mechanisms of adverse drug reactions, and the identification of clinical situations in anaesthesia and surgery where a pathological plasma histamine level may occur. Normal and pathological plasma histamine levels vary considerably in the literature. Data from various studies, especially one involving 300 patients in Heidelberg (G.F.R.), allow us to define the normal range for human plasma histamine as 0–1.0 ng · ml−1. Values greater than 1 ng · ml−1 have to be considered as pathological. The problems related to blood collection and plasma preparation are considered here. Any judgement concerning the method described in the text must take into consideration our long experience of 15 years with it, its reliability in clinical conditions, its practicability, its relatively low cost, and finally, the absence of radioisotopes." @default.
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- W2912858066 date "1982-01-01" @default.
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- W2912858066 title "Le dosage de l'histamine plasmatique lors de réactions anaphylactoïdes chez le sujet anesthésié" @default.
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- W2912858066 doi "https://doi.org/10.1016/s0750-7658(82)80040-3" @default.
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