FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912861305> ?p ?o ?g. }

• W2912861305 endingPage "633" @default.
• W2912861305 startingPage "633" @default.
• W2912861305 abstract "We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE) reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells by modulating key effectors of insulin signalling such as phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) and AMP-activated protein kinase (AMPK). However, the effect of GRE on hepatic insulin resistance is unknown. The effects of GRE on lipid-induced hepatic insulin resistance using palmitate-exposed C3A liver cells and obese insulin resistant (OBIR) rats were explored. GRE attenuated the palmitate-induced impairment of glucose and lipid metabolism in treated C3A cells and improved insulin sensitivity in OBIR rats. Mechanistically, GRE treatment significantly increased PI3K/AKT and AMPK phosphorylation while concurrently enhancing glucose transporter 2 expression. These findings were further supported by marked stimulation of genes involved in glucose metabolism, such as insulin receptor (Insr) and insulin receptor substrate 1 and 2 (Irs1 and Irs2), as well as those involved in lipid metabolism, including Forkhead box protein O1 (FOXO1) and carnitine palmitoyl transferase 1 (CPT1) following GRE treatment. GRE showed a strong potential to ameliorate hepatic insulin resistance by improving insulin sensitivity through the regulation of PI3K/AKT, FOXO1 and AMPK-mediated pathways." @default.
• W2912861305 created "2019-02-21" @default.
• W2912861305 creator A5006611112 @default.
• W2912861305 creator A5014988741 @default.
• W2912861305 creator A5019679724 @default.
• W2912861305 creator A5027176486 @default.
• W2912861305 creator A5027700303 @default.
• W2912861305 creator A5037704297 @default.
• W2912861305 creator A5046068646 @default.
• W2912861305 creator A5046963541 @default.
• W2912861305 creator A5067866694 @default.
• W2912861305 date "2019-02-01" @default.
• W2912861305 modified "2023-10-15" @default.
• W2912861305 title "Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways" @default.
• W2912861305 cites W1216327554 @default.
• W2912861305 cites W1595730385 @default.
• W2912861305 cites W1926685682 @default.
• W2912861305 cites W1977157150 @default.
• W2912861305 cites W1982563578 @default.
• W2912861305 cites W1983167131 @default.
• W2912861305 cites W1996200878 @default.
• W2912861305 cites W2001405761 @default.
• W2912861305 cites W2005112725 @default.
• W2912861305 cites W2013257399 @default.
• W2912861305 cites W2017820712 @default.
• W2912861305 cites W2019194227 @default.
• W2912861305 cites W2024024805 @default.
• W2912861305 cites W2026454288 @default.
• W2912861305 cites W2037918682 @default.
• W2912861305 cites W2044517155 @default.
• W2912861305 cites W2050020603 @default.
• W2912861305 cites W2060216215 @default.
• W2912861305 cites W2061429720 @default.
• W2912861305 cites W2080863734 @default.
• W2912861305 cites W2087410169 @default.
• W2912861305 cites W2087725768 @default.
• W2912861305 cites W2094166298 @default.
• W2912861305 cites W2095689326 @default.
• W2912861305 cites W2104754537 @default.
• W2912861305 cites W2108552132 @default.
• W2912861305 cites W2109371472 @default.
• W2912861305 cites W2114160990 @default.
• W2912861305 cites W2116240218 @default.
• W2912861305 cites W2117499294 @default.
• W2912861305 cites W2128001813 @default.
• W2912861305 cites W2137940993 @default.
• W2912861305 cites W2138226825 @default.
• W2912861305 cites W2139800002 @default.
• W2912861305 cites W2160234571 @default.
• W2912861305 cites W2160741950 @default.
• W2912861305 cites W2164612869 @default.
• W2912861305 cites W2208192379 @default.
• W2912861305 cites W2223868498 @default.
• W2912861305 cites W2238800297 @default.
• W2912861305 cites W2319983393 @default.
• W2912861305 cites W2385632907 @default.
• W2912861305 cites W2397256171 @default.
• W2912861305 cites W2474616143 @default.
• W2912861305 cites W2544022733 @default.
• W2912861305 cites W2570033002 @default.
• W2912861305 cites W2571984714 @default.
• W2912861305 cites W2584060009 @default.
• W2912861305 cites W2605056435 @default.
• W2912861305 cites W2607031541 @default.
• W2912861305 cites W2661327045 @default.
• W2912861305 cites W2734942196 @default.
• W2912861305 cites W2744621892 @default.
• W2912861305 cites W2769280160 @default.
• W2912861305 cites W2885646155 @default.
• W2912861305 cites W584821587 @default.
• W2912861305 doi "https://doi.org/10.3390/ijms20030633" @default.
• W2912861305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6387445" @default.
• W2912861305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30717198" @default.
• W2912861305 hasPublicationYear "2019" @default.
• W2912861305 type Work @default.
• W2912861305 sameAs 2912861305 @default.
• W2912861305 citedByCount "53" @default.
• W2912861305 countsByYear W29128613052019 @default.
• W2912861305 countsByYear W29128613052020 @default.
• W2912861305 countsByYear W29128613052021 @default.
• W2912861305 countsByYear W29128613052022 @default.
• W2912861305 countsByYear W29128613052023 @default.
• W2912861305 crossrefType "journal-article" @default.
• W2912861305 hasAuthorship W2912861305A5006611112 @default.
• W2912861305 hasAuthorship W2912861305A5014988741 @default.
• W2912861305 hasAuthorship W2912861305A5019679724 @default.
• W2912861305 hasAuthorship W2912861305A5027176486 @default.
• W2912861305 hasAuthorship W2912861305A5027700303 @default.
• W2912861305 hasAuthorship W2912861305A5037704297 @default.
• W2912861305 hasAuthorship W2912861305A5046068646 @default.
• W2912861305 hasAuthorship W2912861305A5046963541 @default.
• W2912861305 hasAuthorship W2912861305A5067866694 @default.
• W2912861305 hasBestOaLocation W29128613051 @default.
• W2912861305 hasConcept C112446052 @default.
• W2912861305 hasConcept C126322002 @default.
• W2912861305 hasConcept C134018914 @default.
• W2912861305 hasConcept C140149449 @default.
• W2912861305 hasConcept C161573976 @default.

• next