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- W2912861413 abstract "Background: Ankle-brachial index (ABI) has been linked to the risk of cardiovascular events. However, the association between long-term exposure to air pollution and abnormal ABI has not been fully investigated.Methods: This cross-sectional study involved 4,544 participants from the KORA Study (2004-2008) in the region of Augsburg, Germany. Participants’ residential annual mean concentrations of particulate matter and nitrogen dioxide were predicted with land-use regression models, and the traffic information was collected from geographic information systems. We applied multinomial logistic regression models to assess the effects of air pollution on the prevalence of low and high ABI, and quantile regression models to explore the non-monotonic relationship between air pollution and ABI.Results: Long-term exposure to particulate matter with an aerodynamic diameter ≤ 10 µm (PM10) and ≤ 2.5 µm (PM2.5) was significantly associated with the prevalence of low ABI (ABI < 0.9), with the respective odds ratios (ORs) of 1.78 (95%CI: 1.09-2.92) and 1.63 (95%CI: 1.03-2.58) for an increment from the 5th to the 95th percentile in concentration. For high ABI (ABI > 1.3), the association was significant for PM2.5 absorbance (OR = 1.54, 95%CI: 1.07-2.24) and traffic load within 100 m of the residence (OR = 1.39, 95%CI: 1.04-1.86). Quantile regression analyses revealed similar results.Conclusions: Long-term exposure to particulate matter and traffic-related air pollution was associated with higher prevalence of low and high ABI, respectively, indicating the adverse effects of air pollution on atherosclerosis and arterial stiffness in lower extremities." @default.
- W2912861413 created "2019-02-21" @default.
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- W2912861413 date "2018-09-24" @default.
- W2912861413 modified "2023-09-27" @default.
- W2912861413 title "Long-Term Effects of Air Pollution on Ankle-Brachial Index" @default.
- W2912861413 doi "https://doi.org/10.1289/isesisee.2018.o03.02.01" @default.
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