Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912863469> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2912863469 abstract "Somatic evolution of cancer involves a series of mutations, and attendant changes, in one or more clones of cells. A bad luck type model assumes chance accumulation of mutations. The clonal expansion model assumes, on the other hand, that any mutation leading to partial loss of regulation of cell proliferation will give a selective advantage to the mutant. However, a number of experiments show that an intermediate pre-cancer mutant has only a conditional selective advantage. Given that tissue microenvironmental conditions differ across individual organisms, this selective advantage to a mutant could be widely distributed over the population of organisms. We evaluate three models, namely bad luck, context-independent, and -dependent selection, in a comparative framework, on their ability to predict patterns in total incidence, age-specific incidence, and their ability to explain Peto's paradox. Results show that context dependence is necessary and sufficient to explain observed epidemiological patterns, and that cancer incidence is largely selection-limited, rather than mutation-limited. A wide range of physiological, genetic and behavioural factors influence the tissue micro-environment, and could therefore be the source of this context dependence in somatic evolution of cancer. The identification and targeting of these micro-environmental factors that influence the dynamics of selection offer new possibilities for cancer prevention." @default.
- W2912863469 created "2019-02-21" @default.
- W2912863469 creator A5065280925 @default.
- W2912863469 creator A5084566851 @default.
- W2912863469 date "2019-02-06" @default.
- W2912863469 modified "2023-09-25" @default.
- W2912863469 title "Context-dependent selection as the keystone in somatic evolution of cancer" @default.
- W2912863469 cites W1967304777 @default.
- W2912863469 cites W1977902779 @default.
- W2912863469 cites W1988441135 @default.
- W2912863469 cites W2013611655 @default.
- W2912863469 cites W2019078072 @default.
- W2912863469 cites W2026109069 @default.
- W2912863469 cites W2034269086 @default.
- W2912863469 cites W2059437408 @default.
- W2912863469 cites W2063740593 @default.
- W2912863469 cites W2100124680 @default.
- W2912863469 cites W2109948920 @default.
- W2912863469 cites W2131494886 @default.
- W2912863469 cites W2149308203 @default.
- W2912863469 cites W2158016433 @default.
- W2912863469 cites W2166016923 @default.
- W2912863469 cites W2441755798 @default.
- W2912863469 cites W2524881570 @default.
- W2912863469 cites W2604024577 @default.
- W2912863469 cites W2611387862 @default.
- W2912863469 cites W2620242164 @default.
- W2912863469 cites W2741253009 @default.
- W2912863469 cites W2769390339 @default.
- W2912863469 doi "https://doi.org/10.1101/542290" @default.
- W2912863469 hasPublicationYear "2019" @default.
- W2912863469 type Work @default.
- W2912863469 sameAs 2912863469 @default.
- W2912863469 citedByCount "0" @default.
- W2912863469 crossrefType "posted-content" @default.
- W2912863469 hasAuthorship W2912863469A5065280925 @default.
- W2912863469 hasAuthorship W2912863469A5084566851 @default.
- W2912863469 hasBestOaLocation W29128634691 @default.
- W2912863469 hasConcept C104317684 @default.
- W2912863469 hasConcept C113968399 @default.
- W2912863469 hasConcept C121608353 @default.
- W2912863469 hasConcept C134305767 @default.
- W2912863469 hasConcept C138885662 @default.
- W2912863469 hasConcept C143065580 @default.
- W2912863469 hasConcept C144024400 @default.
- W2912863469 hasConcept C149923435 @default.
- W2912863469 hasConcept C151730666 @default.
- W2912863469 hasConcept C154945302 @default.
- W2912863469 hasConcept C27206212 @default.
- W2912863469 hasConcept C2779343474 @default.
- W2912863469 hasConcept C2908647359 @default.
- W2912863469 hasConcept C41008148 @default.
- W2912863469 hasConcept C501734568 @default.
- W2912863469 hasConcept C54355233 @default.
- W2912863469 hasConcept C61783943 @default.
- W2912863469 hasConcept C70721500 @default.
- W2912863469 hasConcept C78458016 @default.
- W2912863469 hasConcept C81917197 @default.
- W2912863469 hasConcept C86803240 @default.
- W2912863469 hasConcept C98638677 @default.
- W2912863469 hasConceptScore W2912863469C104317684 @default.
- W2912863469 hasConceptScore W2912863469C113968399 @default.
- W2912863469 hasConceptScore W2912863469C121608353 @default.
- W2912863469 hasConceptScore W2912863469C134305767 @default.
- W2912863469 hasConceptScore W2912863469C138885662 @default.
- W2912863469 hasConceptScore W2912863469C143065580 @default.
- W2912863469 hasConceptScore W2912863469C144024400 @default.
- W2912863469 hasConceptScore W2912863469C149923435 @default.
- W2912863469 hasConceptScore W2912863469C151730666 @default.
- W2912863469 hasConceptScore W2912863469C154945302 @default.
- W2912863469 hasConceptScore W2912863469C27206212 @default.
- W2912863469 hasConceptScore W2912863469C2779343474 @default.
- W2912863469 hasConceptScore W2912863469C2908647359 @default.
- W2912863469 hasConceptScore W2912863469C41008148 @default.
- W2912863469 hasConceptScore W2912863469C501734568 @default.
- W2912863469 hasConceptScore W2912863469C54355233 @default.
- W2912863469 hasConceptScore W2912863469C61783943 @default.
- W2912863469 hasConceptScore W2912863469C70721500 @default.
- W2912863469 hasConceptScore W2912863469C78458016 @default.
- W2912863469 hasConceptScore W2912863469C81917197 @default.
- W2912863469 hasConceptScore W2912863469C86803240 @default.
- W2912863469 hasConceptScore W2912863469C98638677 @default.
- W2912863469 hasLocation W29128634691 @default.
- W2912863469 hasOpenAccess W2912863469 @default.
- W2912863469 hasPrimaryLocation W29128634691 @default.
- W2912863469 hasRelatedWork W1915370682 @default.
- W2912863469 hasRelatedWork W1976343644 @default.
- W2912863469 hasRelatedWork W1985403293 @default.
- W2912863469 hasRelatedWork W2029091203 @default.
- W2912863469 hasRelatedWork W2030298439 @default.
- W2912863469 hasRelatedWork W2037211654 @default.
- W2912863469 hasRelatedWork W2141278777 @default.
- W2912863469 hasRelatedWork W2592974799 @default.
- W2912863469 hasRelatedWork W2912863469 @default.
- W2912863469 hasRelatedWork W1986850625 @default.
- W2912863469 isParatext "false" @default.
- W2912863469 isRetracted "false" @default.
- W2912863469 magId "2912863469" @default.
- W2912863469 workType "article" @default.