FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912863706> ?p ?o ?g. }

• W2912863706 endingPage "18.2019" @default.
• W2912863706 startingPage "ENEURO.0300" @default.
• W2912863706 abstract "Abstract Prematurity is associated with significantly increased risk of neurobehavioral pathologies, including autism and schizophrenia. A common feature of these psychiatric disorders is prefrontal cortex (PFC) inhibitory circuit disruption due to GABAergic interneuron alteration. Cortical interneurons are generated and migrate throughout late gestation and early infancy, making them highly susceptible to perinatal insults such as preterm birth. Term and preterm PFC pathology specimens were assessed using immunohistochemical markers for interneurons. Based on the changes seen, a new preterm encephalopathy mouse model was developed to produce similar PFC interneuron loss. Maternal immune activation (MIA; modeling chorioamnionitis, associated with 85% of extremely preterm births) was combined with chronic sublethal hypoxia (CSH; modeling preterm respiratory failure), with offspring of both sexes assessed anatomically, molecularly and neurobehaviorally. In the PFC examined from the human preterm samples compared to matched term samples at corrected age, a decrease in somatostatin (SST) and calbindin (CLB) interneurons was seen in upper cortical layers. This pattern of interneuron loss in upper cortical layers was mimicked in the mouse PFC following the combination of MIA and CSH, but not after either insult alone. This persistent interneuron loss is associated with postnatal microglial activation that occurs during CSH only after MIA. The combined insults lead to long-term neurobehavioral deficits which parallel human psychopathologies that may be seen after extremely preterm birth. This new preclinical model supports a paradigm in which specific cellular alterations seen in preterm encephalopathy can be linked with a risk of neuropsychiatric sequela. Specific interneuron subtypes may provide therapeutic targets to prevent or ameliorate these neurodevelopmental risks." @default.
• W2912863706 created "2019-02-21" @default.
• W2912863706 creator A5007874041 @default.
• W2912863706 creator A5015364268 @default.
• W2912863706 creator A5023513227 @default.
• W2912863706 creator A5040175104 @default.
• W2912863706 creator A5059923566 @default.
• W2912863706 creator A5087689457 @default.
• W2912863706 date "2019-01-01" @default.
• W2912863706 modified "2023-10-10" @default.
• W2912863706 title "Impaired Interneuron Development in a Novel Model of Neonatal Brain Injury" @default.
• W2912863706 cites W1465198550 @default.
• W2912863706 cites W1597975739 @default.
• W2912863706 cites W1727961109 @default.
• W2912863706 cites W1967833315 @default.
• W2912863706 cites W1970957503 @default.
• W2912863706 cites W1975767398 @default.
• W2912863706 cites W1979089999 @default.
• W2912863706 cites W1980100912 @default.
• W2912863706 cites W1985400815 @default.
• W2912863706 cites W1986219188 @default.
• W2912863706 cites W1989756662 @default.
• W2912863706 cites W1992192122 @default.
• W2912863706 cites W1996228517 @default.
• W2912863706 cites W1999106379 @default.
• W2912863706 cites W1999375126 @default.
• W2912863706 cites W2004544578 @default.
• W2912863706 cites W2011183628 @default.
• W2912863706 cites W2012253237 @default.
• W2912863706 cites W2017638524 @default.
• W2912863706 cites W2020651859 @default.
• W2912863706 cites W2022230955 @default.
• W2912863706 cites W2024956393 @default.
• W2912863706 cites W2026432860 @default.
• W2912863706 cites W2032093297 @default.
• W2912863706 cites W2035027696 @default.
• W2912863706 cites W2045096194 @default.
• W2912863706 cites W2052297858 @default.
• W2912863706 cites W2061672452 @default.
• W2912863706 cites W2062334451 @default.
• W2912863706 cites W2064723143 @default.
• W2912863706 cites W2068510638 @default.
• W2912863706 cites W2069985888 @default.
• W2912863706 cites W2070965033 @default.
• W2912863706 cites W2082352870 @default.
• W2912863706 cites W2085848150 @default.
• W2912863706 cites W2087404320 @default.
• W2912863706 cites W2089156150 @default.
• W2912863706 cites W2095185373 @default.
• W2912863706 cites W2098914660 @default.
• W2912863706 cites W2105598663 @default.
• W2912863706 cites W2107713038 @default.
• W2912863706 cites W2114935488 @default.
• W2912863706 cites W2126843605 @default.
• W2912863706 cites W2129283634 @default.
• W2912863706 cites W2136337975 @default.
• W2912863706 cites W2141899840 @default.
• W2912863706 cites W2146427707 @default.
• W2912863706 cites W2149839371 @default.
• W2912863706 cites W2151686210 @default.
• W2912863706 cites W2158463114 @default.
• W2912863706 cites W2161166148 @default.
• W2912863706 cites W2163497473 @default.
• W2912863706 cites W2166266395 @default.
• W2912863706 cites W2170696995 @default.
• W2912863706 cites W2176775892 @default.
• W2912863706 cites W2184917663 @default.
• W2912863706 cites W2219458178 @default.
• W2912863706 cites W2258502568 @default.
• W2912863706 cites W2276586942 @default.
• W2912863706 cites W2288107702 @default.
• W2912863706 cites W2294392975 @default.
• W2912863706 cites W2320983896 @default.
• W2912863706 cites W2503929286 @default.
• W2912863706 cites W2529762510 @default.
• W2912863706 cites W2531096663 @default.
• W2912863706 cites W2605618896 @default.
• W2912863706 cites W2607108802 @default.
• W2912863706 cites W2610528914 @default.
• W2912863706 cites W2766056161 @default.
• W2912863706 cites W2883640526 @default.
• W2912863706 cites W2952743173 @default.
• W2912863706 doi "https://doi.org/10.1523/eneuro.0300-18.2019" @default.
• W2912863706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6390196" @default.
• W2912863706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30809588" @default.
• W2912863706 hasPublicationYear "2019" @default.
• W2912863706 type Work @default.
• W2912863706 sameAs 2912863706 @default.
• W2912863706 citedByCount "31" @default.
• W2912863706 countsByYear W29128637062019 @default.
• W2912863706 countsByYear W29128637062020 @default.
• W2912863706 countsByYear W29128637062021 @default.
• W2912863706 countsByYear W29128637062022 @default.
• W2912863706 countsByYear W29128637062023 @default.
• W2912863706 crossrefType "journal-article" @default.
• W2912863706 hasAuthorship W2912863706A5007874041 @default.
• W2912863706 hasAuthorship W2912863706A5015364268 @default.
• W2912863706 hasAuthorship W2912863706A5023513227 @default.

• next