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• W2912872495 abstract "To determine the effects of a fluid distribution timetable on adherence to fluid restriction of patients with end-stage renal disease undergoing haemodialysis. Fluid restriction is necessary among patients with chronic kidney disease. However, treatment adherence remains a challenge. Single-blind, randomized-controlled pilot study. From September - December 2016, 24 consecutively-selected patients with end-stage renal disease from a single dialysis clinic were randomly assigned using computer-generated sequences of randomly permuted blocks stratified according to gender to receive the fluid distribution timetable or standard care. Adherence to fluid restriction was measured using two indicators—thirst and interdialytic weight gain– and were compared using One-way RM-MANOVA and MANCOVA. Secondary outcomes included baseline patient demographic and clinical characteristics and were compared according to treatment allocation. Both groups were followed-up for 4 weeks, assessing outcome measures during the second haemodialysis session for each week. At baseline, the demographic and clinical characteristics and indicators of adherence to fluid restriction were comparable between the two groups. Thirst scores, however, were statistically lower in the treatment group than the control group on the fourth week follow-up. There was also a remarkable decrease from baseline thirst and interdialytic weight gain scores in the treatment group, with partial eta-squared of 0.43 and 0.39, respectively. The fluid distribution timetable was an effective adjunct treatment strategy in promoting adherence to fluid restriction. However, since this is just a pilot study, further investigation must be conducted to determine the effects of fluid distribution timetable. NCT03582592. 确定液体分配时间表对血液透析终末期肾病患者坚持体液限制的影响。 慢性肾脏病患者必须进行体液限制。 但是,治疗依从度仍然是挑战。 单盲、随机对照法初步研究。 2016年9月至12月,从某个肾脏透析中心先后选择24名终末期肾病患者,使用由计算机生成并按性别分层的随机排列块序列对患者进行随机分配,以遵循液体分配时间表或接受标准护理。使用两个指标(口渴和透析期间体重增加)测量对液体限制的依从度,并使用单向重复多变量方差分析(RM-MANOVA)和多变量方差分析(MANCOVA)法进行比较。次要结果包括患者人口统计基线和临床特征,并根据治疗方法进行分组比较。两组均需要进行为期4周的随访,并在每周第二次血液透析期间对结果进行评估。 在基线状态,两组之间的人口统计和临床特征以及体液限制依从指标具备可比性。然而,在第四周的随访中,我们经统计发现治疗组的口渴评分低于对照组。而治疗组的口渴评分和透析期间体重增加评分也显著降低,其部分埃塔平方值分别为0.43和0.39。 液体分配时间表是促进遵守液体限制的有效辅助治疗策略。然而,由于我们只进行了初步研究,必须进行进一步的研究,以确定液体分配时间表的具体影响。 NCT03582592。 The authors declare no conflict of interest." @default.
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• W2912872495 date "2019-03-18" @default.
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• W2912872495 title "Fluid distribution timetable on adherence to fluid restriction of patients with end‐stage renal disease undergoing haemodialysis: Single‐blind, Randomized‐Controlled Pilot Study" @default.
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