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• W2912875038 abstract "•Preoperative prediction of IDH genotype facilitates pre-treatment decision making for astrocytoma. •DKI could depict the non-Gaussian water molecule diffusion. •DKI has the superiority over DTI in detecting micro-structural changes. •We showed that DKI was more accurate and stable than DTI to evaluate IDH genotype for astrocytoma. AIM To compare the value of diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) in evaluating astrocytomas with an isocitrate dehydrogenase (IDH) genotype. MATERIALS AND METHODS Fifty-eight astrocytomas were divided into IDH-wild-type (IDH-W) and IDH-mutant (IDH-M) groups, in all astrocytomas, low-grade astrocytomas (LGA) and high-grade astrocytomas (HGA), respectively. The DKI (mean kurtosis [MK], radial kurtosis [Kr], axial kurtosis [Ka]), and DTI (fractional anisotropy [FA], mean diffusivity [MD]) values were measured. The differences of parameter values between the IDH-W and IDH-M groups were compared by t-test. Receiver operating characteristic (ROC) curves were used to identify the best parameter and z-score tests were used to compare the performance between DKI and DTI. RESULTS In all astrocytomas, MK, Ka, and Kr values were significantly higher (p<0.001, p=0.002, and p<0.001), and the MD value (p=0.005) was lower in the IDH-W group than those in the IDH-M group. The areas under the ROC curve (AUC) of MK (0.811) and Kr (0.800) were significantly higher than that of MD (0.704). In LGA, MK, Ka, and Kr values were also significantly higher in the IDH-W group than those in the IDH-M group (p=0.002, p=0.008, p=0.006), whereas MD and FA values showed no differences. In HGA, MK and Kr values were significantly higher (p=0.008, p=0.003), and the MD value (p=0.031) was significantly lower in the IDH-W group than that in the IDH-M group, the AUC of MK (0.750) and Kr (0.788) were also higher than MD (0.637; p=0.032, p=0.025). CONCLUSION DKI may be a new imaging biomarker for evaluating the IDH genotype of astrocytomas, which is more accurate and stable than DTI. To compare the value of diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) in evaluating astrocytomas with an isocitrate dehydrogenase (IDH) genotype. Fifty-eight astrocytomas were divided into IDH-wild-type (IDH-W) and IDH-mutant (IDH-M) groups, in all astrocytomas, low-grade astrocytomas (LGA) and high-grade astrocytomas (HGA), respectively. The DKI (mean kurtosis [MK], radial kurtosis [Kr], axial kurtosis [Ka]), and DTI (fractional anisotropy [FA], mean diffusivity [MD]) values were measured. The differences of parameter values between the IDH-W and IDH-M groups were compared by t-test. Receiver operating characteristic (ROC) curves were used to identify the best parameter and z-score tests were used to compare the performance between DKI and DTI. In all astrocytomas, MK, Ka, and Kr values were significantly higher (p<0.001, p=0.002, and p<0.001), and the MD value (p=0.005) was lower in the IDH-W group than those in the IDH-M group. The areas under the ROC curve (AUC) of MK (0.811) and Kr (0.800) were significantly higher than that of MD (0.704). In LGA, MK, Ka, and Kr values were also significantly higher in the IDH-W group than those in the IDH-M group (p=0.002, p=0.008, p=0.006), whereas MD and FA values showed no differences. In HGA, MK and Kr values were significantly higher (p=0.008, p=0.003), and the MD value (p=0.031) was significantly lower in the IDH-W group than that in the IDH-M group, the AUC of MK (0.750) and Kr (0.788) were also higher than MD (0.637; p=0.032, p=0.025). DKI may be a new imaging biomarker for evaluating the IDH genotype of astrocytomas, which is more accurate and stable than DTI." @default.
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• W2912875038 date "2019-04-01" @default.
• W2912875038 modified "2023-10-16" @default.
• W2912875038 title "Comparing the value of DKI and DTI in detecting isocitrate dehydrogenase genotype of astrocytomas" @default.
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• W2912875038 doi "https://doi.org/10.1016/j.crad.2018.12.004" @default.
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