Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912880171> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2912880171 endingPage "168a" @default.
- W2912880171 startingPage "168a" @default.
- W2912880171 abstract "Revealing protein conformations are essential for determining protein structure and dynamics, including its function and interaction with the environment, for understanding disease mechanisms. However, it is challenging for biophysical methods to resolve multiple conformations, especially at longer distances, limiting their application to few biological systems. Pulsed Dipolar Electron Spin Resonance Spectroscopy (PDS) is powerful method for obtaining conformations between the distance ranges of 1 to 10 nm. In PDS, a dipolar signal is acquired from the interaction between a pair of spin labels, from which the distance distribution between them, P(r) may be obtained. However, due to the ill-posed nature of the inversion of the dipolar signal to yield the P(r), one must resort to Tikhonov regularization or model fitting methods to obtain reasonable results. They either compromise between good resolution and stability of the P(r) or require a priori model functions to estimate P(r), which may not accurately represent the actual distance distributions. This is especially true if the P(r) is multimodal. We developed a new and objective approach based on singular value decomposition that yields an optimum approximate solution.1 Instead of solving for the complete distance distribution all at once, the method finds the optimal distribution value at each distance or distance range by determining each of their different singular value cut-offs.2 The new method ensures optimal convergence at all distance ranges, accurately retrieving high resolution multimodal distributions representing multiple conformations.1,2 (1) Srivastava, Freed (2017) J. Phys. Chem. Lett.8, 5648 (2) Srivastava, Freed (under revision) J. Phys. Chem. A" @default.
- W2912880171 created "2019-02-21" @default.
- W2912880171 creator A5016966558 @default.
- W2912880171 creator A5082585459 @default.
- W2912880171 date "2019-02-01" @default.
- W2912880171 modified "2023-09-30" @default.
- W2912880171 title "Revealing Multiple Conformations of Proteins at Long Distances by using Singular Value Decomposition Method in Pulsed Dipolar ESR Spectroscopy" @default.
- W2912880171 doi "https://doi.org/10.1016/j.bpj.2018.11.935" @default.
- W2912880171 hasPublicationYear "2019" @default.
- W2912880171 type Work @default.
- W2912880171 sameAs 2912880171 @default.
- W2912880171 citedByCount "0" @default.
- W2912880171 crossrefType "journal-article" @default.
- W2912880171 hasAuthorship W2912880171A5016966558 @default.
- W2912880171 hasAuthorship W2912880171A5082585459 @default.
- W2912880171 hasBestOaLocation W29128801711 @default.
- W2912880171 hasConcept C109282560 @default.
- W2912880171 hasConcept C111472728 @default.
- W2912880171 hasConcept C112972136 @default.
- W2912880171 hasConcept C11413529 @default.
- W2912880171 hasConcept C119857082 @default.
- W2912880171 hasConcept C121332964 @default.
- W2912880171 hasConcept C121864883 @default.
- W2912880171 hasConcept C134306372 @default.
- W2912880171 hasConcept C135252773 @default.
- W2912880171 hasConcept C138885662 @default.
- W2912880171 hasConcept C152442038 @default.
- W2912880171 hasConcept C158693339 @default.
- W2912880171 hasConcept C173523689 @default.
- W2912880171 hasConcept C178790620 @default.
- W2912880171 hasConcept C185592680 @default.
- W2912880171 hasConcept C186060115 @default.
- W2912880171 hasConcept C22789450 @default.
- W2912880171 hasConcept C33923547 @default.
- W2912880171 hasConcept C41008148 @default.
- W2912880171 hasConcept C46141821 @default.
- W2912880171 hasConcept C62520636 @default.
- W2912880171 hasConcept C75553542 @default.
- W2912880171 hasConcept C86803240 @default.
- W2912880171 hasConceptScore W2912880171C109282560 @default.
- W2912880171 hasConceptScore W2912880171C111472728 @default.
- W2912880171 hasConceptScore W2912880171C112972136 @default.
- W2912880171 hasConceptScore W2912880171C11413529 @default.
- W2912880171 hasConceptScore W2912880171C119857082 @default.
- W2912880171 hasConceptScore W2912880171C121332964 @default.
- W2912880171 hasConceptScore W2912880171C121864883 @default.
- W2912880171 hasConceptScore W2912880171C134306372 @default.
- W2912880171 hasConceptScore W2912880171C135252773 @default.
- W2912880171 hasConceptScore W2912880171C138885662 @default.
- W2912880171 hasConceptScore W2912880171C152442038 @default.
- W2912880171 hasConceptScore W2912880171C158693339 @default.
- W2912880171 hasConceptScore W2912880171C173523689 @default.
- W2912880171 hasConceptScore W2912880171C178790620 @default.
- W2912880171 hasConceptScore W2912880171C185592680 @default.
- W2912880171 hasConceptScore W2912880171C186060115 @default.
- W2912880171 hasConceptScore W2912880171C22789450 @default.
- W2912880171 hasConceptScore W2912880171C33923547 @default.
- W2912880171 hasConceptScore W2912880171C41008148 @default.
- W2912880171 hasConceptScore W2912880171C46141821 @default.
- W2912880171 hasConceptScore W2912880171C62520636 @default.
- W2912880171 hasConceptScore W2912880171C75553542 @default.
- W2912880171 hasConceptScore W2912880171C86803240 @default.
- W2912880171 hasIssue "3" @default.
- W2912880171 hasLocation W29128801711 @default.
- W2912880171 hasOpenAccess W2912880171 @default.
- W2912880171 hasPrimaryLocation W29128801711 @default.
- W2912880171 hasRelatedWork W1877883502 @default.
- W2912880171 hasRelatedWork W2012577502 @default.
- W2912880171 hasRelatedWork W2147072251 @default.
- W2912880171 hasRelatedWork W2354503388 @default.
- W2912880171 hasRelatedWork W2362251625 @default.
- W2912880171 hasRelatedWork W2378428125 @default.
- W2912880171 hasRelatedWork W2616678780 @default.
- W2912880171 hasRelatedWork W3046265042 @default.
- W2912880171 hasRelatedWork W3114212224 @default.
- W2912880171 hasRelatedWork W4200162047 @default.
- W2912880171 hasVolume "116" @default.
- W2912880171 isParatext "false" @default.
- W2912880171 isRetracted "false" @default.
- W2912880171 magId "2912880171" @default.
- W2912880171 workType "article" @default.