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- W2912885360 abstract "El síndrome antifosfolípido se describe como una forma de trombofilia inducida por autoanticuerpos cuyas principales manifestaciones clínicas son las trombosis, tanto venosas como arteriales, y las complicaciones obstétricas recurrentes, fundamentalmente los abortos recurrentes o los partos prematuros. Estos autoanticuerpos son los anticuerpos antifosfolípido que se detectan mediante tres pruebas diagnósticas: test de anticuerpos anticardiolipina (ACL), test de anticuerpos anti-β2-glucoproteína I (β2GPI) y anticoagulante lúpico (AL). Además de las trombosis y las complicaciones obstétricas, estos pacientes pueden presentar otras manifestaciones clínicas como la microangiopatía trombótica renal, las valvulopatías, el deterioro cognitivo o la livedo reticularis. Para su diagnóstico se utilizan los criterios de clasificación de Sidney (2006), que requieren de al menos un criterio clínico y uno analítico. Su tratamiento tiene dos vertientes, la de la profilaxis primaria en pacientes que no han presentado fenómenos previos de trombosis, y la del tratamiento o profilaxis secundaria en pacientes con trombosis previas. Antiphospholipid syndrome is described as a form of autoantibody induced thrombophilia The cardinal symptoms are thrombosis, both venous and arterial, and recurrent obstetric complications, mainly the recurrent abortions or premature deliveries. These autoantibodies are antiphospholipid antibodies that are detected by three diagnostic tests: test for anticardiolipin antibodies (ACL), test of anti β2-glycoprotein I (β2GPI) and lupus anticoagulant (LA). In addition to thrombosis and obstetric complications, these patients may have other clinical manifestations such as renal thrombotic microangiopathy, valvulopathy, cognitive impairment or livedo reticularis. Used for diagnosis classification criteria Sydney (2006), which require at least one clinical and analytical criteria. Your treatment is twofold, that of primary prophylaxis in patients who have not submitted prior thrombosis phenomena, and the treatment or secondary prophylaxis in patients with previous thrombosis" @default.
- W2912885360 created "2019-02-21" @default.
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- W2912885360 date "2013-01-01" @default.
- W2912885360 modified "2023-10-17" @default.
- W2912885360 title "Síndrome antifosfolípido" @default.
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- W2912885360 doi "https://doi.org/10.1016/s0304-5412(13)70565-1" @default.
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