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- W2912890763 endingPage "175628641882191" @default.
- W2912890763 startingPage "175628641882191" @default.
- W2912890763 abstract "Acute ischemic stroke (AIS) remains a major cause of death and disability throughout the world. The most severe form of stroke results from large vessel occlusion of the major branches of the Circle of Willis. The treatment strategies currently available in western countries for large vessel occlusion involve rapid restoration of blood flow through removal of the offending blood clot using mechanical or pharmacological means (e.g. tissue plasma activator; tPA). This review assesses prospects for a novel pharmacological approach to enhance the availability of the natural enzyme tissue kallikrein (KLK1), an important regulator of local blood flow. KLK1 is responsible for the generation of kinins (bradykinin and kallidin), which promote local vasodilation and long-term vascularization. Moreover, KLK1 has been used clinically as a direct treatment for multiple diseases associated with impaired local blood flow including AIS. A form of human KLK1 isolated from human urine is approved in the People’s Republic of China for subacute treatment of AIS. Here we review the rationale for using KLK1 as an additional pharmacological treatment for AIS by providing the biochemical mechanism as well as the human clinical data that support this approach." @default.
- W2912890763 created "2019-02-21" @default.
- W2912890763 creator A5023648089 @default.
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- W2912890763 creator A5091050446 @default.
- W2912890763 date "2019-01-01" @default.
- W2912890763 modified "2023-10-01" @default.
- W2912890763 title "Human tissue kallikrein in the treatment of acute ischemic stroke" @default.
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