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- W2912892994 abstract "Background: The circadian variation of stroke onset has been recognized for decades, and the temporal pattern of stroke onset time, stroke subtypes, first-ever and recurrent stroke has been extensively investigated all over the world. However, little information is available regarding the circadian rhythm of stroke severity. In the present study, we investigated the relationship between stroke onset time and severity on admission in patients with acute ischemic stroke. Method: 305 patients admitted with acute ischemic stroke were consecutively recruited in accordance with IRB approval. Stroke onset time was determined by a neurologist, by questioning patients and/or relatives who observed the onset and who were aware of the last time seen well. Stroke severity was determined by NIH stroke scale (NIHSS) on admission. Result: 100 patients (32.79%) developed ischemic stroke at night (8pm~8am), and 205 (67.21%) had strokes during the day (8am~8pm), which is consistent with previous reports that more patients suffer ischemic strokes while awake than while asleep. Daytime strokes were also more severe than those that occurred at night (Figure 1A and 1B). Patients who developed strokes in the afternoon demonstrated the worst functional status (Figure 1C). Conclusion: Our results explore the circadian variation of the severity of ischemic stroke, which has important therapeutic implications in light of new advances in IA therapy. Further study is ongoing to adjust for confounders such as treatment variation, co-morbidities, social factors, and stroke subtypes." @default.
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- W2912892994 date "2019-02-01" @default.
- W2912892994 modified "2023-09-25" @default.
- W2912892994 title "Abstract TP228: Circadian Rhythm and the Severity of Ischemic Stroke" @default.
- W2912892994 doi "https://doi.org/10.1161/str.50.suppl_1.tp228" @default.
- W2912892994 hasPublicationYear "2019" @default.
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