FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912894877> ?p ?o ?g. }

• W2912894877 endingPage "1908" @default.
• W2912894877 startingPage "1899" @default.
• W2912894877 abstract "Abstract The metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats member 13) prevents microvascular thrombosis by cleaving von Willebrand factor (VWF) within platelet-rich thrombi, and cleavage depends on allosteric activation of ADAMTS13 by the substrate VWF. Human ADAMTS13 has a short propeptide, metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains (proximal domains), followed by 7 T and 2 CUB (complement components C1r and C1s, sea urchin protein Uegf, and bone morphogenetic protein-1) domains (distal domains). Distal domains inhibit the catalytic proximal domains; binding of distal T8-CUB domains to the VWF D4 domain relieves autoinhibition and promotes cleavage of the nearby VWF A2 domain. However, the role of specific ADAMTS13 distal domains in this allosteric mechanism is not established. Assays of plasma ADAMTS13 from 20 placental mammals, birds, and amphibians show that allosteric regulation is broadly conserved, and phylogenetic analysis of 264 vertebrates shows the long propeptide, T3, T4, T6, and T6a domains have been deleted several times in placental mammals, birds, and fish. Notably, pigeon ADAMTS13 has only 3 distal T domains but was activated normally by human VWF D4 and cleaved VWF multimers, preferentially under fluid shear stress. Human ADAMTS13 constructed to resemble pigeon ADAMTS13 retained normal allosteric regulation and shear-dependent cleavage of VWF. Thus, the T3-T6 domains of human ADAMTS13 are dispensable. Conversely, deletion of T7 or T8 abolished allosteric activation. For most species, some sequence changes in the VWF substrate can markedly increase the rate of cleavage, suggesting that ADAMTS13 and VWF have not evolved to be optimal enzyme-substrate pairs. These properties may reflect evolutionary pressure to balance the risk for VWF-dependent bleeding and thrombosis." @default.
• W2912894877 created "2019-02-21" @default.
• W2912894877 creator A5006797684 @default.
• W2912894877 creator A5010065750 @default.
• W2912894877 creator A5016445495 @default.
• W2912894877 creator A5044510198 @default.
• W2912894877 creator A5056625739 @default.
• W2912894877 creator A5065263316 @default.
• W2912894877 creator A5070589320 @default.
• W2912894877 date "2019-04-25" @default.
• W2912894877 modified "2023-10-11" @default.
• W2912894877 title "Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation" @default.
• W2912894877 cites W1942245717 @default.
• W2912894877 cites W1971600900 @default.
• W2912894877 cites W1972595265 @default.
• W2912894877 cites W1974537190 @default.
• W2912894877 cites W1977024178 @default.
• W2912894877 cites W1978858820 @default.
• W2912894877 cites W1996091158 @default.
• W2912894877 cites W2014250508 @default.
• W2912894877 cites W2024542832 @default.
• W2912894877 cites W2035454293 @default.
• W2912894877 cites W2037638635 @default.
• W2912894877 cites W2050360519 @default.
• W2912894877 cites W2053956729 @default.
• W2912894877 cites W2055422733 @default.
• W2912894877 cites W2069779742 @default.
• W2912894877 cites W2079133863 @default.
• W2912894877 cites W2080297087 @default.
• W2912894877 cites W2095299313 @default.
• W2912894877 cites W2112876229 @default.
• W2912894877 cites W2114604545 @default.
• W2912894877 cites W2122536819 @default.
• W2912894877 cites W2124912444 @default.
• W2912894877 cites W2157764784 @default.
• W2912894877 cites W2157956748 @default.
• W2912894877 cites W2170454614 @default.
• W2912894877 cites W2315229770 @default.
• W2912894877 cites W2401660990 @default.
• W2912894877 cites W2522920260 @default.
• W2912894877 cites W2568909523 @default.
• W2912894877 cites W2578619275 @default.
• W2912894877 cites W2588749321 @default.
• W2912894877 cites W276645119 @default.
• W2912894877 doi "https://doi.org/10.1182/blood-2018-11-886275" @default.
• W2912894877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6484387" @default.
• W2912894877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30700419" @default.
• W2912894877 hasPublicationYear "2019" @default.
• W2912894877 type Work @default.
• W2912894877 sameAs 2912894877 @default.
• W2912894877 citedByCount "23" @default.
• W2912894877 countsByYear W29128948772019 @default.
• W2912894877 countsByYear W29128948772020 @default.
• W2912894877 countsByYear W29128948772021 @default.
• W2912894877 countsByYear W29128948772022 @default.
• W2912894877 countsByYear W29128948772023 @default.
• W2912894877 crossrefType "journal-article" @default.
• W2912894877 hasAuthorship W2912894877A5006797684 @default.
• W2912894877 hasAuthorship W2912894877A5010065750 @default.
• W2912894877 hasAuthorship W2912894877A5016445495 @default.
• W2912894877 hasAuthorship W2912894877A5044510198 @default.
• W2912894877 hasAuthorship W2912894877A5056625739 @default.
• W2912894877 hasAuthorship W2912894877A5065263316 @default.
• W2912894877 hasAuthorship W2912894877A5070589320 @default.
• W2912894877 hasBestOaLocation W29128948771 @default.
• W2912894877 hasConcept C109523444 @default.
• W2912894877 hasConcept C151730666 @default.
• W2912894877 hasConcept C166342909 @default.
• W2912894877 hasConcept C167814343 @default.
• W2912894877 hasConcept C175156509 @default.
• W2912894877 hasConcept C181199279 @default.
• W2912894877 hasConcept C185592680 @default.
• W2912894877 hasConcept C203014093 @default.
• W2912894877 hasConcept C2778259572 @default.
• W2912894877 hasConcept C2779394231 @default.
• W2912894877 hasConcept C2780921031 @default.
• W2912894877 hasConcept C43369102 @default.
• W2912894877 hasConcept C55493867 @default.
• W2912894877 hasConcept C55728118 @default.
• W2912894877 hasConcept C86803240 @default.
• W2912894877 hasConcept C89560881 @default.
• W2912894877 hasConcept C95444343 @default.
• W2912894877 hasConceptScore W2912894877C109523444 @default.
• W2912894877 hasConceptScore W2912894877C151730666 @default.
• W2912894877 hasConceptScore W2912894877C166342909 @default.
• W2912894877 hasConceptScore W2912894877C167814343 @default.
• W2912894877 hasConceptScore W2912894877C175156509 @default.
• W2912894877 hasConceptScore W2912894877C181199279 @default.
• W2912894877 hasConceptScore W2912894877C185592680 @default.
• W2912894877 hasConceptScore W2912894877C203014093 @default.
• W2912894877 hasConceptScore W2912894877C2778259572 @default.
• W2912894877 hasConceptScore W2912894877C2779394231 @default.
• W2912894877 hasConceptScore W2912894877C2780921031 @default.
• W2912894877 hasConceptScore W2912894877C43369102 @default.
• W2912894877 hasConceptScore W2912894877C55493867 @default.
• W2912894877 hasConceptScore W2912894877C55728118 @default.
• W2912894877 hasConceptScore W2912894877C86803240 @default.
• W2912894877 hasConceptScore W2912894877C89560881 @default.

• next