FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912896225> ?p ?o ?g. }

• W2912896225 endingPage "577.e6" @default.
• W2912896225 startingPage "567" @default.
• W2912896225 abstract "Action selection is a prerequisite for decision-making and a fundamental aspect to any goal-directed locomotion; it requires integration of sensory signals and internal states to translate them into action sequences. Here, we introduce a novel behavioral analysis to study neural circuits and mechanisms underlying action selection and decision-making in freely moving Drosophila. We discovered preferred patterns of motor activity and turning behavior. These patterns are impaired in FoxP mutant flies, which present an altered temporal organization of motor actions and turning behavior, reminiscent of indecisiveness. Then, focusing on central complex (CX) circuits known to integrate different sensory modalities and controlling premotor regions, we show that action sequences and turning behavior are regulated by dopamine D1-like receptor (Dop1R1) signaling. Dop1R1 inputs onto CX columnar ellipsoid body-protocerebral bridge gall (E-PG) neuron and ellipsoid body (EB) R2/R4m ring neuron circuits both negatively gate motor activity but inversely control turning behavior. Although flies deficient of D1 receptor signaling present normal turning behavior despite decreased activity, restoring Dop1R1 level in R2/R4m-specific circuitry affects the temporal organization of motor actions and turning. We finally show EB R2/R4m neurons are in contact with E-PG neurons that are thought to encode body orientation and heading direction of the fly. These findings suggest that Dop1R1 signaling in E-PG and EB R2/4 m circuits are compared against each other, thereby modulating patterns of activity and turning behavior for goal-directed locomotion." @default.
• W2912896225 created "2019-02-21" @default.
• W2912896225 creator A5003473254 @default.
• W2912896225 creator A5017039936 @default.
• W2912896225 creator A5050413354 @default.
• W2912896225 creator A5086717948 @default.
• W2912896225 date "2019-02-01" @default.
• W2912896225 modified "2023-10-18" @default.
• W2912896225 title "Inverse Control of Turning Behavior by Dopamine D1 Receptor Signaling in Columnar and Ring Neurons of the Central Complex in Drosophila" @default.
• W2912896225 cites W117906282 @default.
• W2912896225 cites W1503270516 @default.
• W2912896225 cites W1956351779 @default.
• W2912896225 cites W1966877506 @default.
• W2912896225 cites W1967531387 @default.
• W2912896225 cites W1969558625 @default.
• W2912896225 cites W1969707662 @default.
• W2912896225 cites W1972309850 @default.
• W2912896225 cites W1972689388 @default.
• W2912896225 cites W1977319682 @default.
• W2912896225 cites W1979641847 @default.
• W2912896225 cites W1987795012 @default.
• W2912896225 cites W1991194524 @default.
• W2912896225 cites W1995723319 @default.
• W2912896225 cites W1996761102 @default.
• W2912896225 cites W2004187422 @default.
• W2912896225 cites W2005511849 @default.
• W2912896225 cites W2007185934 @default.
• W2912896225 cites W2018126536 @default.
• W2912896225 cites W2026297218 @default.
• W2912896225 cites W2030443339 @default.
• W2912896225 cites W2033949300 @default.
• W2912896225 cites W2036137808 @default.
• W2912896225 cites W2043369736 @default.
• W2912896225 cites W2050926740 @default.
• W2912896225 cites W2055015381 @default.
• W2912896225 cites W2076834018 @default.
• W2912896225 cites W2083890928 @default.
• W2912896225 cites W2087767638 @default.
• W2912896225 cites W2089223230 @default.
• W2912896225 cites W2097708062 @default.
• W2912896225 cites W2106524861 @default.
• W2912896225 cites W2117495877 @default.
• W2912896225 cites W2118125647 @default.
• W2912896225 cites W2120792852 @default.
• W2912896225 cites W2131864338 @default.
• W2912896225 cites W2133917215 @default.
• W2912896225 cites W2145341421 @default.
• W2912896225 cites W2155540878 @default.
• W2912896225 cites W2157914830 @default.
• W2912896225 cites W2159669279 @default.
• W2912896225 cites W2162423871 @default.
• W2912896225 cites W2163546388 @default.
• W2912896225 cites W2187369646 @default.
• W2912896225 cites W2274819546 @default.
• W2912896225 cites W2395416306 @default.
• W2912896225 cites W2417735520 @default.
• W2912896225 cites W2581087878 @default.
• W2912896225 cites W2610861664 @default.
• W2912896225 cites W2614915054 @default.
• W2912896225 cites W2739939547 @default.
• W2912896225 cites W2754385040 @default.
• W2912896225 cites W2759093710 @default.
• W2912896225 cites W2799652277 @default.
• W2912896225 cites W2802004087 @default.
• W2912896225 cites W2884269856 @default.
• W2912896225 cites W2951061187 @default.
• W2912896225 cites W2953356325 @default.
• W2912896225 doi "https://doi.org/10.1016/j.cub.2019.01.017" @default.
• W2912896225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6384123" @default.
• W2912896225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30713106" @default.
• W2912896225 hasPublicationYear "2019" @default.
• W2912896225 type Work @default.
• W2912896225 sameAs 2912896225 @default.
• W2912896225 citedByCount "38" @default.
• W2912896225 countsByYear W29128962252019 @default.
• W2912896225 countsByYear W29128962252020 @default.
• W2912896225 countsByYear W29128962252021 @default.
• W2912896225 countsByYear W29128962252022 @default.
• W2912896225 countsByYear W29128962252023 @default.
• W2912896225 crossrefType "journal-article" @default.
• W2912896225 hasAuthorship W2912896225A5003473254 @default.
• W2912896225 hasAuthorship W2912896225A5017039936 @default.
• W2912896225 hasAuthorship W2912896225A5050413354 @default.
• W2912896225 hasAuthorship W2912896225A5086717948 @default.
• W2912896225 hasBestOaLocation W29128962251 @default.
• W2912896225 hasConcept C104317684 @default.
• W2912896225 hasConcept C118403218 @default.
• W2912896225 hasConcept C121332964 @default.
• W2912896225 hasConcept C166109690 @default.
• W2912896225 hasConcept C169760540 @default.
• W2912896225 hasConcept C26486553 @default.
• W2912896225 hasConcept C26760741 @default.
• W2912896225 hasConcept C2776041557 @default.
• W2912896225 hasConcept C2780104201 @default.
• W2912896225 hasConcept C2780791683 @default.
• W2912896225 hasConcept C513476851 @default.
• W2912896225 hasConcept C54355233 @default.
• W2912896225 hasConcept C62520636 @default.

• next