Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912896883> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2912896883 endingPage "286a" @default.
- W2912896883 startingPage "286a" @default.
- W2912896883 abstract "Atherosclerosis is the major underlying cause of cardiovascular disease that can lead to heart attack and stroke. The disease starts with deposition of lipoproteins rich in cholesterol and cholesteryl esters (CE) from the blood into the intimal layer of the vessel walls, and then with inflammation and immune cell infiltration, can progress into advanced plaques. Structural cells that make up the majority of the mechanical properties of the vessel wall, particularly a thick layer of smooth muscle cells in the media, are also infiltrated by lipids and acquire inflammatory-like cell features, with detrimental effects on their structural properties. The objective of this study was to apply diffusion-based molecular imaging of lipids (CE) with new considerations of vascular-tissue structural properties. These studies were performed in a rabbit model of aortic atherosclerosis that resembles many of the stages and features of human plaques, including heterogeneous lipids in advanced inflamed plaques and plaque rupture (thrombosis). Our MRI approach (demonstrated at 11.7T field strength ex vivo) elucidated the lipid contents of plaques in slice-based MR imaging. Further details of anisotropic tissue properties were distinguished with evaluation of three-dimensional lipid diffusion properties. These properties give insights into the architecture of the vessel wall. Compared to healthy rabbit vessel, highly inflamed and rupture-prone plaques contained thick intimal lipid deposits. CE-rich plaques displayed anisotropic diffusion properties resulting from cellular and extra-cellular matrix constituents present in the adjacent vessel wall. Reconstruction of 3D fiber orientation demonstrated anisotropic properties with respect to vessel wall depth. These anisotropic regions are indicative of normal vessel wall, lipid infiltrate, and foam cell expansion. With further development our MRI approach could be used in vivo to expand characterization of atherosclerosis as a disease of the vessel wall." @default.
- W2912896883 created "2019-02-21" @default.
- W2912896883 creator A5019941350 @default.
- W2912896883 creator A5028209802 @default.
- W2912896883 creator A5035920117 @default.
- W2912896883 creator A5041312741 @default.
- W2912896883 creator A5063553486 @default.
- W2912896883 creator A5075779009 @default.
- W2912896883 date "2019-02-01" @default.
- W2912896883 modified "2023-09-26" @default.
- W2912896883 title "Aortic Atherosclerosis with Consideration of the Anisotropic Properties of Lipids in MRI" @default.
- W2912896883 doi "https://doi.org/10.1016/j.bpj.2018.11.1545" @default.
- W2912896883 hasPublicationYear "2019" @default.
- W2912896883 type Work @default.
- W2912896883 sameAs 2912896883 @default.
- W2912896883 citedByCount "0" @default.
- W2912896883 crossrefType "journal-article" @default.
- W2912896883 hasAuthorship W2912896883A5019941350 @default.
- W2912896883 hasAuthorship W2912896883A5028209802 @default.
- W2912896883 hasAuthorship W2912896883A5035920117 @default.
- W2912896883 hasAuthorship W2912896883A5041312741 @default.
- W2912896883 hasAuthorship W2912896883A5063553486 @default.
- W2912896883 hasAuthorship W2912896883A5075779009 @default.
- W2912896883 hasBestOaLocation W29128968831 @default.
- W2912896883 hasConcept C126322002 @default.
- W2912896883 hasConcept C126838900 @default.
- W2912896883 hasConcept C142724271 @default.
- W2912896883 hasConcept C143409427 @default.
- W2912896883 hasConcept C149550507 @default.
- W2912896883 hasConcept C153400128 @default.
- W2912896883 hasConcept C159985019 @default.
- W2912896883 hasConcept C185592680 @default.
- W2912896883 hasConcept C192562407 @default.
- W2912896883 hasConcept C2776914184 @default.
- W2912896883 hasConcept C2777663904 @default.
- W2912896883 hasConcept C2777895019 @default.
- W2912896883 hasConcept C2778163477 @default.
- W2912896883 hasConcept C2779179121 @default.
- W2912896883 hasConcept C2780072125 @default.
- W2912896883 hasConcept C55493867 @default.
- W2912896883 hasConcept C71924100 @default.
- W2912896883 hasConceptScore W2912896883C126322002 @default.
- W2912896883 hasConceptScore W2912896883C126838900 @default.
- W2912896883 hasConceptScore W2912896883C142724271 @default.
- W2912896883 hasConceptScore W2912896883C143409427 @default.
- W2912896883 hasConceptScore W2912896883C149550507 @default.
- W2912896883 hasConceptScore W2912896883C153400128 @default.
- W2912896883 hasConceptScore W2912896883C159985019 @default.
- W2912896883 hasConceptScore W2912896883C185592680 @default.
- W2912896883 hasConceptScore W2912896883C192562407 @default.
- W2912896883 hasConceptScore W2912896883C2776914184 @default.
- W2912896883 hasConceptScore W2912896883C2777663904 @default.
- W2912896883 hasConceptScore W2912896883C2777895019 @default.
- W2912896883 hasConceptScore W2912896883C2778163477 @default.
- W2912896883 hasConceptScore W2912896883C2779179121 @default.
- W2912896883 hasConceptScore W2912896883C2780072125 @default.
- W2912896883 hasConceptScore W2912896883C55493867 @default.
- W2912896883 hasConceptScore W2912896883C71924100 @default.
- W2912896883 hasIssue "3" @default.
- W2912896883 hasLocation W29128968831 @default.
- W2912896883 hasOpenAccess W2912896883 @default.
- W2912896883 hasPrimaryLocation W29128968831 @default.
- W2912896883 hasRelatedWork W1509542786 @default.
- W2912896883 hasRelatedWork W1971404868 @default.
- W2912896883 hasRelatedWork W2058590148 @default.
- W2912896883 hasRelatedWork W2060747458 @default.
- W2912896883 hasRelatedWork W2576982802 @default.
- W2912896883 hasRelatedWork W2885257262 @default.
- W2912896883 hasRelatedWork W2989351400 @default.
- W2912896883 hasRelatedWork W3150460578 @default.
- W2912896883 hasRelatedWork W3172499390 @default.
- W2912896883 hasRelatedWork W3176677135 @default.
- W2912896883 hasVolume "116" @default.
- W2912896883 isParatext "false" @default.
- W2912896883 isRetracted "false" @default.
- W2912896883 magId "2912896883" @default.
- W2912896883 workType "article" @default.