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- W2912897219 endingPage "1153" @default.
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- W2912897219 abstract "Actin filament-associated protein 1-antisense RNA1 (AFAP1-AS1), a cancer-related long non-coding RNA, has been found to be upregulated in multiple types of cancers. AFAP1-AS1 is important for the initiation, progression and poor prognosis of many cancers, including nasopharyngeal carcinoma (NPC). However, the mechanism underlying the regulation of AFAP1-AS1 expression is not well-understood. In our study, the potential promoter region of AFAP1-AS1 was predicted by comprehensive bioinformatics analysis. Moreover, promoter deletion analysis identified the sequence between positions -359 and -28 bp as the minimal promoter region of AFAP1-AS1. The ChIP assay results indicate that the AFAP1-AS1 promoter is responsive to the transcription factor c-Myc, which can promote high AFAP1-AS1 expression. This study is the first to clone and characterize the AFAP1-AS1 promoter region. Our findings will help to better understand the underlying mechanism of high AFAP1-AS1 expression in tumorigenesis and to develop new strategies for therapeutic high expression of AFAP1-AS1 in NPC." @default.
- W2912897219 created "2019-02-21" @default.
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- W2912897219 date "2019-01-01" @default.
- W2912897219 modified "2023-10-12" @default.
- W2912897219 title "Cloning and characterization of the putative AFAP1-AS1 promoter region" @default.
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- W2912897219 doi "https://doi.org/10.7150/jca.29049" @default.
- W2912897219 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6400686" @default.
- W2912897219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30854123" @default.
- W2912897219 hasPublicationYear "2019" @default.
- W2912897219 type Work @default.