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• W2912902030 abstract "Background/Aim: Maternal folic acid (FA) protects against developmental toxicity from certain environmental chemicals. Our objective was to examine combined exposures to maternal FA and pesticides, in relation to autism spectrum disorder (ASD). Methods: Participants were California children born 2000-2007, enrolled in the CHARGE case-control study at age 2-5 years, clinically confirmed to have ASD (n=296) or typical development (n= 220) and had information on maternal supplemental FA and pesticide exposures. Maternal supplemental FA and household pesticide product use were retrospectively collected in telephone interviews from 2003-2011. Mothers’ addresses were linked to a statewide database of commercial applications to estimate agricultural pesticide exposure. Results: Above median FA intake (≥ 800µg) during the first pregnancy month and no known pesticide exposure was the reference group for all analyses. Compared with this group, ASD was increased in association with <800µg FA and any indoor pesticide exposure (adjusted OR=2.5; 95% CI: 1.3, 4.7) compared to low FA (OR=1.2; 95% CI: 0.7, 2.2) or indoor pesticides (OR=1.7; 95% CI: 1.1, 2.8) alone. ORs for the combination of low FA and regular pregnancy exposure (6+ months) to pet pesticides or outdoor sprays and foggers were 3.9 (1.4, 11.5) and 4.1 (1.7, 10.1), respectively. ORs for low maternal FA and agricultural pesticide exposure 3 months before or after conception were: 2.2 (0.7, 6.5) for chlorpyrifos, 2.3 (0.98, 5.3) for organophosphates, 2.1 (0.9, 4.8) for pyrethroids, and 1.5 (0.5, 4.8) for carbamates. Except for carbamates, these ORs were about two times greater than those for either exposure alone, or for the expected multiplicative or additive combined ORs. Conclusions: In this study population, associations between pesticide exposures and ASD were attenuated among those with high versus low FA intake during the first month of pregnancy. Confirmatory and mechanistic studies are needed." @default.
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• W2912902030 date "2018-02-01" @default.
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• W2912902030 title "Combined Exposures to Prenatal Pesticides and Folic Acid Intake in Relation to Autism Spectrum Disorder" @default.
• W2912902030 doi "https://doi.org/10.1289/isee.2017.2017-983" @default.
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