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• W2912902832 endingPage "788" @default.
• W2912902832 startingPage "781" @default.
• W2912902832 abstract "Many Gram-negative pathogens utilize dedicated secretion systems to export virulence factors such as exotoxins and effectors1-4. Several exotoxins are synthesized as precursors containing amino-terminal Sec signal peptides and are exported through the inner-membrane-bound Sec machinery to the periplasm, followed by secretion across the outer membrane to the exterior using a type II secretion system (T2SS)3,5. Here, we report that thermostable direct haemolysin (TDH), an exotoxin of the food-borne pathogen Vibrio parahaemolyticus, can be exported through the type III secretion system (T3SS), which engages in one-step secretion of effectors4, despite possessing a Sec signal peptide and being mainly secreted via the T2SS. Although the precursor of TDH is targeted to the Sec pathway, a fraction of mature TDH was observed to re-enter the bacterial cytoplasm. The N terminus of mature TDH comprises a T3SS signal sequence, allowing it to be loaded into the T3SS. We also show that T3SS-delivered TDH as an effector contributes to intestinal fluid accumulation in a rabbit diarrhoeal model of V. parahaemolyticus infection. Thus, our results show that an unconventional export mechanism for a bacterial toxin via the T3SS in tandem with the Sec machinery facilitates the virulence trait of V. parahaemolyticus." @default.
• W2912902832 created "2019-02-21" @default.
• W2912902832 creator A5008212926 @default.
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• W2912902832 date "2019-02-18" @default.
• W2912902832 modified "2023-10-17" @default.
• W2912902832 title "Export of a Vibrio parahaemolyticus toxin by the Sec and type III secretion machineries in tandem" @default.
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• W2912902832 doi "https://doi.org/10.1038/s41564-019-0368-y" @default.
• W2912902832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30778145" @default.
• W2912902832 hasPublicationYear "2019" @default.
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