FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912903776> ?p ?o ?g. }

• W2912903776 abstract "The role of IFN-induced genes (ISGs) in viral infection remains incompletely understood. While most ISGs are antiviral, some ISGs have been shown to promote viral infection, including HIV-1 infection. We previously showed that IFN-inducible LY6E protein promotes HIV-1 infection in human PMBCs and high-CD4-expressing SupT1 cells. Here we found that LY6E inhibits HIV-1 entry and replication in low-CD4-expressing MDMs and Jurkat cells. Mechanistically, we demonstrated that LY6E downregulates the cell surface receptor CD4, thus impairing the virus binding to target cells. This is in contrast to the situation of high-CD4-expressing cells, where LY6E predominantly promotes viral membrane fusion. The opposing role of IFN-inducible LY6E in modulating HIV-1 infection highlights the complex roles of ISGs in viral infection and viral pathogenesis." @default.
• W2912903776 created "2019-02-21" @default.
• W2912903776 creator A5015246989 @default.
• W2912903776 creator A5044530218 @default.
• W2912903776 creator A5062868933 @default.
• W2912903776 date "2019-04-01" @default.
• W2912903776 modified "2023-10-18" @default.
• W2912903776 title "CD4-Dependent Modulation of HIV-1 Entry by LY6E" @default.
• W2912903776 cites W1504625876 @default.
• W2912903776 cites W1592794964 @default.
• W2912903776 cites W1635401440 @default.
• W2912903776 cites W1793476185 @default.
• W2912903776 cites W1816372920 @default.
• W2912903776 cites W1931451499 @default.
• W2912903776 cites W1933898011 @default.
• W2912903776 cites W1972029847 @default.
• W2912903776 cites W1972163715 @default.
• W2912903776 cites W1974804326 @default.
• W2912903776 cites W1978435298 @default.
• W2912903776 cites W1982769349 @default.
• W2912903776 cites W1995355944 @default.
• W2912903776 cites W1998016101 @default.
• W2912903776 cites W2003812878 @default.
• W2912903776 cites W2009909482 @default.
• W2912903776 cites W2014818809 @default.
• W2912903776 cites W2023528999 @default.
• W2912903776 cites W2025346994 @default.
• W2912903776 cites W2030541908 @default.
• W2912903776 cites W2038504202 @default.
• W2912903776 cites W2041081262 @default.
• W2912903776 cites W2045224288 @default.
• W2912903776 cites W2047247630 @default.
• W2912903776 cites W2062454172 @default.
• W2912903776 cites W2067164933 @default.
• W2912903776 cites W2071776498 @default.
• W2912903776 cites W2077620427 @default.
• W2912903776 cites W2078646756 @default.
• W2912903776 cites W2084803259 @default.
• W2912903776 cites W2085464725 @default.
• W2912903776 cites W2086264258 @default.
• W2912903776 cites W2090666457 @default.
• W2912903776 cites W2094068975 @default.
• W2912903776 cites W2099774120 @default.
• W2912903776 cites W2102018921 @default.
• W2912903776 cites W2108256128 @default.
• W2912903776 cites W2112032807 @default.
• W2912903776 cites W2113282092 @default.
• W2912903776 cites W2118545611 @default.
• W2912903776 cites W2119870029 @default.
• W2912903776 cites W2125377515 @default.
• W2912903776 cites W2139171197 @default.
• W2912903776 cites W2141199943 @default.
• W2912903776 cites W2144206275 @default.
• W2912903776 cites W2151168963 @default.
• W2912903776 cites W2151672077 @default.
• W2912903776 cites W2153776880 @default.
• W2912903776 cites W2157914777 @default.
• W2912903776 cites W2158478900 @default.
• W2912903776 cites W2219893450 @default.
• W2912903776 cites W2259290952 @default.
• W2912903776 cites W2338841302 @default.
• W2912903776 cites W2417724913 @default.
• W2912903776 cites W2513337708 @default.
• W2912903776 cites W2580066664 @default.
• W2912903776 cites W2586254930 @default.
• W2912903776 cites W2795784950 @default.
• W2912903776 cites W2889114972 @default.
• W2912903776 doi "https://doi.org/10.1128/jvi.01866-18" @default.
• W2912903776 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6430548" @default.
• W2912903776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30674630" @default.
• W2912903776 hasPublicationYear "2019" @default.
• W2912903776 type Work @default.
• W2912903776 sameAs 2912903776 @default.
• W2912903776 citedByCount "19" @default.
• W2912903776 countsByYear W29129037762019 @default.
• W2912903776 countsByYear W29129037762020 @default.
• W2912903776 countsByYear W29129037762021 @default.
• W2912903776 countsByYear W29129037762022 @default.
• W2912903776 countsByYear W29129037762023 @default.
• W2912903776 crossrefType "journal-article" @default.
• W2912903776 hasAuthorship W2912903776A5015246989 @default.
• W2912903776 hasAuthorship W2912903776A5044530218 @default.
• W2912903776 hasAuthorship W2912903776A5062868933 @default.
• W2912903776 hasBestOaLocation W29129037761 @default.
• W2912903776 hasConcept C140704245 @default.
• W2912903776 hasConcept C159047783 @default.
• W2912903776 hasConcept C179464577 @default.
• W2912903776 hasConcept C203014093 @default.
• W2912903776 hasConcept C2522874641 @default.
• W2912903776 hasConcept C2776090121 @default.
• W2912903776 hasConcept C3013748606 @default.
• W2912903776 hasConcept C58475186 @default.
• W2912903776 hasConcept C86803240 @default.
• W2912903776 hasConcept C8891405 @default.
• W2912903776 hasConcept C95444343 @default.
• W2912903776 hasConceptScore W2912903776C140704245 @default.
• W2912903776 hasConceptScore W2912903776C159047783 @default.
• W2912903776 hasConceptScore W2912903776C179464577 @default.
• W2912903776 hasConceptScore W2912903776C203014093 @default.
• W2912903776 hasConceptScore W2912903776C2522874641 @default.

• next