FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912905081> ?p ?o ?g. }

• W2912905081 endingPage "1665" @default.
• W2912905081 startingPage "1653" @default.
• W2912905081 abstract "The aim of this work was to investigate the clinicopathological significance of fibrinogen gamma chain (FGG) and its biological roles during hepatocellular carcinoma (HCC) development and progression.The expression of FGG was examined by Western blot and reverse transcription quantitative PCR in two different sample sets, including 24 or 35 pairs of HCC tumor tissues and their corresponding adjacent non-tumorous tissues. Afterward, association analysis between the expression of FGG and clinicopathological characteristics was systematically analyzed in 79 HCC patients. Subsequently, the mobility and invasiveness of SK-HEP-1 cells with FGG overexpression or knockdown were evaluated by transwell assay and wound healing assay. Additionally, the expressions of epithelial to mesenchymal transition (EMT)-associated markers were also detected in FGG overexpressed or silenced SK-HEP-1 cells.The expression of FGG was significantly increased in primary HCC tissues comparing with its corresponding adjacent non-tumorous tissues. Clinical pathological analysis demonstrated that upregulation of intracellular FGG was significantly associated with increased vascular invasion, more satellite nodules, and more advanced TNM stage, and HCC patients with stronger expression of FGG had a higher recurrence rate and correspondingly a shorter overall survival time. Meanwhile, the high expression of FGG was also proved to be an independent risk factor for disease-free survival after surgical resection. In vitro phenotype studies showed that overexpression of FGG could promote the migration and invasion in SK-HEP-1 cells; conversely, these phenotypes could be significantly inhibited by knocking down the expression of FGG. Mechanism studies indicated that FGG could promote the migration and invasion through EMT signaling pathway by regulating the expressions of Slug and ZEB1.FGG played important roles in enhancing cancer cell motility and invasiveness through EMT signaling, and might serve as a potential prognostic biomarker for HCC patients." @default.
• W2912905081 created "2019-02-21" @default.
• W2912905081 creator A5018554864 @default.
• W2912905081 creator A5028666112 @default.
• W2912905081 creator A5031804038 @default.
• W2912905081 creator A5046026008 @default.
• W2912905081 creator A5047737377 @default.
• W2912905081 creator A5055365138 @default.
• W2912905081 creator A5061568119 @default.
• W2912905081 creator A5066911305 @default.
• W2912905081 creator A5068473447 @default.
• W2912905081 creator A5075080019 @default.
• W2912905081 creator A5081245050 @default.
• W2912905081 creator A5086529957 @default.
• W2912905081 date "2019-02-01" @default.
• W2912905081 modified "2023-10-17" @default.
• W2912905081 title "<p>FGG promotes migration and invasion in hepatocellular carcinoma cells through activating epithelial to mesenchymal transition</p>" @default.
• W2912905081 cites W1480706413 @default.
• W2912905081 cites W1482962573 @default.
• W2912905081 cites W1804495077 @default.
• W2912905081 cites W1869829470 @default.
• W2912905081 cites W1964847767 @default.
• W2912905081 cites W1987504267 @default.
• W2912905081 cites W1993749140 @default.
• W2912905081 cites W1998625450 @default.
• W2912905081 cites W2025647419 @default.
• W2912905081 cites W2038469938 @default.
• W2912905081 cites W2038573728 @default.
• W2912905081 cites W2059158933 @default.
• W2912905081 cites W2069449301 @default.
• W2912905081 cites W2071609983 @default.
• W2912905081 cites W2078132464 @default.
• W2912905081 cites W2114363335 @default.
• W2912905081 cites W2133583163 @default.
• W2912905081 cites W2137696271 @default.
• W2912905081 cites W2143814414 @default.
• W2912905081 cites W2152400371 @default.
• W2912905081 cites W2520522929 @default.
• W2912905081 cites W2526396529 @default.
• W2912905081 cites W2572149156 @default.
• W2912905081 cites W2605607341 @default.
• W2912905081 cites W2761278542 @default.
• W2912905081 cites W2779085518 @default.
• W2912905081 cites W2788650664 @default.
• W2912905081 cites W2806189561 @default.
• W2912905081 cites W2806330118 @default.
• W2912905081 cites W2885849110 @default.
• W2912905081 cites W2889646458 @default.
• W2912905081 cites W2979234090 @default.
• W2912905081 cites W4211233744 @default.
• W2912905081 cites W49012675 @default.
• W2912905081 doi "https://doi.org/10.2147/cmar.s188248" @default.
• W2912905081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6389006" @default.
• W2912905081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30863175" @default.
• W2912905081 hasPublicationYear "2019" @default.
• W2912905081 type Work @default.
• W2912905081 sameAs 2912905081 @default.
• W2912905081 citedByCount "25" @default.
• W2912905081 countsByYear W29129050812019 @default.
• W2912905081 countsByYear W29129050812020 @default.
• W2912905081 countsByYear W29129050812021 @default.
• W2912905081 countsByYear W29129050812022 @default.
• W2912905081 countsByYear W29129050812023 @default.
• W2912905081 crossrefType "journal-article" @default.
• W2912905081 hasAuthorship W2912905081A5018554864 @default.
• W2912905081 hasAuthorship W2912905081A5028666112 @default.
• W2912905081 hasAuthorship W2912905081A5031804038 @default.
• W2912905081 hasAuthorship W2912905081A5046026008 @default.
• W2912905081 hasAuthorship W2912905081A5047737377 @default.
• W2912905081 hasAuthorship W2912905081A5055365138 @default.
• W2912905081 hasAuthorship W2912905081A5061568119 @default.
• W2912905081 hasAuthorship W2912905081A5066911305 @default.
• W2912905081 hasAuthorship W2912905081A5068473447 @default.
• W2912905081 hasAuthorship W2912905081A5075080019 @default.
• W2912905081 hasAuthorship W2912905081A5081245050 @default.
• W2912905081 hasAuthorship W2912905081A5086529957 @default.
• W2912905081 hasBestOaLocation W29129050811 @default.
• W2912905081 hasConcept C104317684 @default.
• W2912905081 hasConcept C127561419 @default.
• W2912905081 hasConcept C137738243 @default.
• W2912905081 hasConcept C142724271 @default.
• W2912905081 hasConcept C173396325 @default.
• W2912905081 hasConcept C198826908 @default.
• W2912905081 hasConcept C2776415932 @default.
• W2912905081 hasConcept C2778019345 @default.
• W2912905081 hasConcept C502942594 @default.
• W2912905081 hasConcept C54355233 @default.
• W2912905081 hasConcept C55493867 @default.
• W2912905081 hasConcept C71924100 @default.
• W2912905081 hasConcept C76419328 @default.
• W2912905081 hasConcept C81885089 @default.
• W2912905081 hasConcept C86803240 @default.
• W2912905081 hasConceptScore W2912905081C104317684 @default.
• W2912905081 hasConceptScore W2912905081C127561419 @default.
• W2912905081 hasConceptScore W2912905081C137738243 @default.
• W2912905081 hasConceptScore W2912905081C142724271 @default.
• W2912905081 hasConceptScore W2912905081C173396325 @default.
• W2912905081 hasConceptScore W2912905081C198826908 @default.

• next