FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912908036> ?p ?o ?g. }

• W2912908036 abstract "The long non-coding RNA (lncRNA) Maternally Expressed Gene 3 (Meg3) is encoded within the imprinted Dlk1-Meg3 gene locus and is only maternally expressed. Meg3 has been shown to play an important role in the regulation of cellular proliferation and functions as a tumor suppressor in numerous tissues. Meg3 is highly expressed in mouse adult hematopoietic stem cells (HSCs) and strongly down-regulated in early progenitors. To address its functional role in HSCs, we used MxCre to conditionally delete Meg3 in the adult bone marrow of Meg3mat-flox/pat-wt mice. We performed extensive in vitro and in vivo analyses of mice carrying a Meg3 deficient blood system, but neither observed impaired hematopoiesis during homeostatic conditions nor upon serial transplantation. Furthermore, we analyzed VavCre Meg3mat-flox/pat-wt mice, in which Meg3 was deleted in the embryonic hematopoietic system and unexpectedly this did neither generate any hematopoietic defects. In response to interferon-mediated stimulation, Meg3 deficient adult HSCs responded highly similar compared to controls. Taken together, we report the finding, that the highly expressed imprinted lncRNA Meg3 is dispensable for the function of HSCs during homeostasis and in response to stress mediators as well as for serial reconstitution of the blood system in vivo." @default.
• W2912908036 created "2019-02-21" @default.
• W2912908036 creator A5012493352 @default.
• W2912908036 creator A5013850498 @default.
• W2912908036 creator A5025350997 @default.
• W2912908036 creator A5034090492 @default.
• W2912908036 creator A5038486025 @default.
• W2912908036 creator A5039581367 @default.
• W2912908036 creator A5041250002 @default.
• W2912908036 creator A5054016255 @default.
• W2912908036 creator A5079877160 @default.
• W2912908036 creator A5081292832 @default.
• W2912908036 creator A5081577791 @default.
• W2912908036 creator A5091178940 @default.
• W2912908036 date "2019-02-14" @default.
• W2912908036 modified "2023-10-11" @default.
• W2912908036 title "The long non-coding RNA Meg3 is dispensable for hematopoietic stem cells" @default.
• W2912908036 cites W1978683461 @default.
• W2912908036 cites W1980052833 @default.
• W2912908036 cites W1989126702 @default.
• W2912908036 cites W1999307118 @default.
• W2912908036 cites W2011059916 @default.
• W2912908036 cites W2014462590 @default.
• W2912908036 cites W2014677321 @default.
• W2912908036 cites W2029664411 @default.
• W2912908036 cites W2031855875 @default.
• W2912908036 cites W2037377496 @default.
• W2912908036 cites W2038970416 @default.
• W2912908036 cites W2052350491 @default.
• W2912908036 cites W2055129041 @default.
• W2912908036 cites W2070154483 @default.
• W2912908036 cites W2072411272 @default.
• W2912908036 cites W2074291164 @default.
• W2912908036 cites W2083033504 @default.
• W2912908036 cites W2083941735 @default.
• W2912908036 cites W2099176640 @default.
• W2912908036 cites W2103121534 @default.
• W2912908036 cites W2103546044 @default.
• W2912908036 cites W2105495977 @default.
• W2912908036 cites W2110918588 @default.
• W2912908036 cites W2126591572 @default.
• W2912908036 cites W2127376251 @default.
• W2912908036 cites W2127746941 @default.
• W2912908036 cites W2131271579 @default.
• W2912908036 cites W2140288082 @default.
• W2912908036 cites W2142043313 @default.
• W2912908036 cites W2154699417 @default.
• W2912908036 cites W2169856474 @default.
• W2912908036 cites W2170551349 @default.
• W2912908036 cites W2171577249 @default.
• W2912908036 cites W2178620944 @default.
• W2912908036 cites W2179438025 @default.
• W2912908036 cites W2607089824 @default.
• W2912908036 cites W2610808603 @default.
• W2912908036 cites W2756150334 @default.
• W2912908036 cites W4252030004 @default.
• W2912908036 doi "https://doi.org/10.1038/s41598-019-38605-8" @default.
• W2912908036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6375991" @default.
• W2912908036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30765776" @default.
• W2912908036 hasPublicationYear "2019" @default.
• W2912908036 type Work @default.
• W2912908036 sameAs 2912908036 @default.
• W2912908036 citedByCount "15" @default.
• W2912908036 countsByYear W29129080362020 @default.
• W2912908036 countsByYear W29129080362021 @default.
• W2912908036 countsByYear W29129080362022 @default.
• W2912908036 countsByYear W29129080362023 @default.
• W2912908036 crossrefType "journal-article" @default.
• W2912908036 hasAuthorship W2912908036A5012493352 @default.
• W2912908036 hasAuthorship W2912908036A5013850498 @default.
• W2912908036 hasAuthorship W2912908036A5025350997 @default.
• W2912908036 hasAuthorship W2912908036A5034090492 @default.
• W2912908036 hasAuthorship W2912908036A5038486025 @default.
• W2912908036 hasAuthorship W2912908036A5039581367 @default.
• W2912908036 hasAuthorship W2912908036A5041250002 @default.
• W2912908036 hasAuthorship W2912908036A5054016255 @default.
• W2912908036 hasAuthorship W2912908036A5079877160 @default.
• W2912908036 hasAuthorship W2912908036A5081292832 @default.
• W2912908036 hasAuthorship W2912908036A5081577791 @default.
• W2912908036 hasAuthorship W2912908036A5091178940 @default.
• W2912908036 hasBestOaLocation W29129080361 @default.
• W2912908036 hasConcept C104317684 @default.
• W2912908036 hasConcept C109159458 @default.
• W2912908036 hasConcept C126322002 @default.
• W2912908036 hasConcept C201750760 @default.
• W2912908036 hasConcept C2781369401 @default.
• W2912908036 hasConcept C28328180 @default.
• W2912908036 hasConcept C2911091166 @default.
• W2912908036 hasConcept C502942594 @default.
• W2912908036 hasConcept C54355233 @default.
• W2912908036 hasConcept C62203573 @default.
• W2912908036 hasConcept C67705224 @default.
• W2912908036 hasConcept C71924100 @default.
• W2912908036 hasConcept C86803240 @default.
• W2912908036 hasConcept C95444343 @default.
• W2912908036 hasConceptScore W2912908036C104317684 @default.
• W2912908036 hasConceptScore W2912908036C109159458 @default.
• W2912908036 hasConceptScore W2912908036C126322002 @default.
• W2912908036 hasConceptScore W2912908036C201750760 @default.
• W2912908036 hasConceptScore W2912908036C2781369401 @default.

• next