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- W2912910161 abstract "Background Adrenocortical carcinoma is a rare and heterogeneous malignancy with poor outcomes. Recent research has suggested that outcomes may be improved by centralization of care in specialist centres. We review our evolving 21‐year experience in managing adrenocortical carcinoma with a view towards outcomes and lessons learnt. Methods A retrospective study of patients treated in our specialist endocrine surgical unit over 21 years was undertaken. Results Thirty‐five patients were treated from diagnosis, 29 forming a primary study cohort. Additionally, seven patients were referred to us for quaternary care, forming a secondary study cohort. The European Network for the Study of Adrenal Tumours (ENSAT) stage and immunohistochemical marker Ki‐67 index were strong prognostic indicators for survival. Conclusions Early stage, complete resection and Ki‐67 <10% are the best prognosticators for survival. Aggressive surgical resection at index operation and of recurrent oligometastatic disease along with multimodal adjuvant treatment has led to long‐term survivors of patients with Stage 4 disease in our aggregate cohort." @default.
- W2912910161 created "2019-02-21" @default.
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- W2912910161 date "2019-01-01" @default.
- W2912910161 modified "2023-09-25" @default.
- W2912910161 title "Treatment and management of adrenal cancer in a specialized Australian endocrine surgical unit: approaches, outcomes and lessons learnt" @default.
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- W2912910161 doi "https://doi.org/10.1111/ans.15032" @default.
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