Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912911060> ?p ?o ?g. }
- W2912911060 abstract "Abstract Impairments of dendritic trees and spines have been found in many neurodegenerative diseases, including Alzheimer's disease (AD), in which the deficits of melatonin signal pathway were reported. Melatonin receptor 2 (MT2) is widely expressed in the hippocampus and mediates the biological functions of melatonin. It is known that melatonin application is protective to dendritic abnormalities in AD. However, whether MT2 is involved in the neuroprotection and the underlying mechanisms are not clear. Here, we first found that MT2 is dramatically reduced in the dendritic compartment upon the insult of oligomer Aβ. MT2 activation prevented the Aβ‐induced disruption of dendritic complexity and spine. Importantly, activation of MT2 decreased cAMP, which in turn inactivated transcriptional factor CCAAT/enhancer‐binding protein α(C/EBPα) to suppress miR‐125b expression and elevate the expression of its target, GluN2A. In addition, miR‐125b mimics fully blocked the protective effects of MT2 activation on dendritic trees and spines. Finally, injection of a lentivirus containing a miR‐125b sponge into the hippocampus of APP/PS1 mice effectively rescued the dendritic abnormalities and learning/memory impairments. Our data demonstrated that the cAMP‐C/EBPα/miR‐125b/GluN2A signaling pathway is important to the neuroprotective effects of MT2 activation in Aβ‐induced dendritic injuries and learning/memory disorders, providing a novel therapeutic target for the treatment of AD synaptopathy." @default.
- W2912911060 created "2019-02-21" @default.
- W2912911060 creator A5006012404 @default.
- W2912911060 creator A5009050901 @default.
- W2912911060 creator A5009811665 @default.
- W2912911060 creator A5010496812 @default.
- W2912911060 creator A5016780114 @default.
- W2912911060 creator A5038390604 @default.
- W2912911060 creator A5045382404 @default.
- W2912911060 creator A5046610319 @default.
- W2912911060 creator A5059342849 @default.
- W2912911060 creator A5060503081 @default.
- W2912911060 creator A5065103961 @default.
- W2912911060 creator A5069619699 @default.
- W2912911060 creator A5079367600 @default.
- W2912911060 creator A5083691450 @default.
- W2912911060 date "2019-02-01" @default.
- W2912911060 modified "2023-10-18" @default.
- W2912911060 title "Activation of MT2 receptor ameliorates dendritic abnormalities in Alzheimer’s disease via C/EBPα/miR‐125b pathway" @default.
- W2912911060 cites W1504296704 @default.
- W2912911060 cites W1552396365 @default.
- W2912911060 cites W1563702802 @default.
- W2912911060 cites W1649036316 @default.
- W2912911060 cites W1963490664 @default.
- W2912911060 cites W1968553823 @default.
- W2912911060 cites W1993812537 @default.
- W2912911060 cites W1997890299 @default.
- W2912911060 cites W2008612988 @default.
- W2912911060 cites W2014739744 @default.
- W2912911060 cites W2017824514 @default.
- W2912911060 cites W2022807604 @default.
- W2912911060 cites W2030594918 @default.
- W2912911060 cites W2033960866 @default.
- W2912911060 cites W2037024495 @default.
- W2912911060 cites W2037778691 @default.
- W2912911060 cites W2038940805 @default.
- W2912911060 cites W2042985303 @default.
- W2912911060 cites W2063646837 @default.
- W2912911060 cites W2084062482 @default.
- W2912911060 cites W2093816451 @default.
- W2912911060 cites W2103040176 @default.
- W2912911060 cites W2115988763 @default.
- W2912911060 cites W2117391623 @default.
- W2912911060 cites W2123329342 @default.
- W2912911060 cites W2124159333 @default.
- W2912911060 cites W2126552458 @default.
- W2912911060 cites W2137417139 @default.
- W2912911060 cites W2143819289 @default.
- W2912911060 cites W2148159882 @default.
- W2912911060 cites W2148340578 @default.
- W2912911060 cites W2149715915 @default.
- W2912911060 cites W2151132444 @default.
- W2912911060 cites W2154757857 @default.
- W2912911060 cites W2159558884 @default.
- W2912911060 cites W2479394673 @default.
- W2912911060 cites W2587706314 @default.
- W2912911060 cites W2587974852 @default.
- W2912911060 cites W2599042613 @default.
- W2912911060 cites W2600940151 @default.
- W2912911060 cites W2608824639 @default.
- W2912911060 cites W2611672506 @default.
- W2912911060 cites W2743219260 @default.
- W2912911060 cites W2768018325 @default.
- W2912911060 cites W3023013291 @default.
- W2912911060 cites W4239641604 @default.
- W2912911060 doi "https://doi.org/10.1111/acel.12902" @default.
- W2912911060 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6413662" @default.
- W2912911060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30706990" @default.
- W2912911060 hasPublicationYear "2019" @default.
- W2912911060 type Work @default.
- W2912911060 sameAs 2912911060 @default.
- W2912911060 citedByCount "29" @default.
- W2912911060 countsByYear W29129110602019 @default.
- W2912911060 countsByYear W29129110602020 @default.
- W2912911060 countsByYear W29129110602021 @default.
- W2912911060 countsByYear W29129110602022 @default.
- W2912911060 countsByYear W29129110602023 @default.
- W2912911060 crossrefType "journal-article" @default.
- W2912911060 hasAuthorship W2912911060A5006012404 @default.
- W2912911060 hasAuthorship W2912911060A5009050901 @default.
- W2912911060 hasAuthorship W2912911060A5009811665 @default.
- W2912911060 hasAuthorship W2912911060A5010496812 @default.
- W2912911060 hasAuthorship W2912911060A5016780114 @default.
- W2912911060 hasAuthorship W2912911060A5038390604 @default.
- W2912911060 hasAuthorship W2912911060A5045382404 @default.
- W2912911060 hasAuthorship W2912911060A5046610319 @default.
- W2912911060 hasAuthorship W2912911060A5059342849 @default.
- W2912911060 hasAuthorship W2912911060A5060503081 @default.
- W2912911060 hasAuthorship W2912911060A5065103961 @default.
- W2912911060 hasAuthorship W2912911060A5069619699 @default.
- W2912911060 hasAuthorship W2912911060A5079367600 @default.
- W2912911060 hasAuthorship W2912911060A5083691450 @default.
- W2912911060 hasBestOaLocation W29129110601 @default.
- W2912911060 hasConcept C104317684 @default.
- W2912911060 hasConcept C148762608 @default.
- W2912911060 hasConcept C149240914 @default.
- W2912911060 hasConcept C169760540 @default.
- W2912911060 hasConcept C170493617 @default.
- W2912911060 hasConcept C174884520 @default.
- W2912911060 hasConcept C25498285 @default.