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- W2912921911 abstract "Dynamic kinetic resolution (DKR) of racemic aryl α-amino β-ketoesters via Ru-diphosphine-catalyzed asymmetric hydrogenation was realized at 70 °C under 50 atm of hydrogen, affording syn α-amido β-hydroxy esters in high yields (up to 96%) with high reactivity (TON up to 940) and diastereo- and enantioselectivities (up to 99:1 dr, 98% ee). These hydrogenation products provide valuable chiral synthons in many natural products and pharmaceuticals. Gram-scale DKR asymmetric hydrogenation (DKR-AH) was also performed with retained reactivity and stereoselectivity, revealing the synthetic utility of this method." @default.
- W2912921911 created "2019-02-21" @default.
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- W2912921911 date "2019-02-19" @default.
- W2912921911 modified "2023-10-14" @default.
- W2912921911 title "Highly Diastereo- and Enantioselective Access to <i>syn</i>-α-Amido β-Hydroxy Esters via Ruthenium-Catalyzed Dynamic Kinetic Resolution-Asymmetric Hydrogenation" @default.
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- W2912921911 doi "https://doi.org/10.1021/acs.joc.8b03106" @default.
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