Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912931895> ?p ?o ?g. }
- W2912931895 endingPage "890" @default.
- W2912931895 startingPage "881" @default.
- W2912931895 abstract "We explored the effects of a mucoadhesive formulation containing curcuminoid (MFC) from Curcuma longa L. extract on oral mucositis (OM) induced by 5-fluorouracil (5-FU) in hamsters. Seventy-two golden Syrian hamsters were randomly allocated into four groups: control, placebo, chamomilla, and MFC. Animals received an intraperitoneal injection of 5-FU at Days 0 and 2. On Days 3 and 4, the buccal mucosa was scratched. Therapy was initiated on Day 5. Animals received two applications of the substances per day according to the experimental group. Six animals were euthanized on Days 8, 10, and 14. Clinical analysis were performed using photography and histopathological sections of 3 μm were stained by hematoxylin-eosin for semiquantitative analysis of re-epithelization and inflammation. Immunohistochemistry was used for angiogenesis (CD31) and transforming growth factor beta 1 (TGF-β1) analysis. On Day 5, all groups exhibited OM. Clinical and histopathological findings revealed that on Day 8, both MFC and chamomilla groups exhibited better wound healing. In addition, the MFC group demonstrated lower angiogenesis and TGF-β1 levels on Day 8 compared with placebo and control groups. Collectively, these findings suggest that MFC has a therapeutic effect on OM, accelerating wound healing through re-epithelization and anti-inflammatory action as modulation of angiogenesis and TGF-β1 expression." @default.
- W2912931895 created "2019-02-21" @default.
- W2912931895 creator A5007342889 @default.
- W2912931895 creator A5026813880 @default.
- W2912931895 creator A5035417445 @default.
- W2912931895 creator A5038721765 @default.
- W2912931895 creator A5044514486 @default.
- W2912931895 creator A5047114970 @default.
- W2912931895 creator A5082251390 @default.
- W2912931895 creator A5085825839 @default.
- W2912931895 date "2019-01-23" @default.
- W2912931895 modified "2023-10-01" @default.
- W2912931895 title "Mucoadhesive formulation containing <scp> <i>Curcuma longa</i> </scp> L. reduces oral mucositis induced by 5‐fluorouracil in hamsters" @default.
- W2912931895 cites W1588145958 @default.
- W2912931895 cites W1838490851 @default.
- W2912931895 cites W1969257164 @default.
- W2912931895 cites W1975852815 @default.
- W2912931895 cites W1987108013 @default.
- W2912931895 cites W1991178530 @default.
- W2912931895 cites W1997584913 @default.
- W2912931895 cites W2005129970 @default.
- W2912931895 cites W2008892442 @default.
- W2912931895 cites W2011647149 @default.
- W2912931895 cites W2035846616 @default.
- W2912931895 cites W2039915343 @default.
- W2912931895 cites W2042389554 @default.
- W2912931895 cites W2045809449 @default.
- W2912931895 cites W2061251554 @default.
- W2912931895 cites W2077431908 @default.
- W2912931895 cites W2087342203 @default.
- W2912931895 cites W2094717383 @default.
- W2912931895 cites W2100010018 @default.
- W2912931895 cites W2106800142 @default.
- W2912931895 cites W2107779823 @default.
- W2912931895 cites W2111640373 @default.
- W2912931895 cites W2131357228 @default.
- W2912931895 cites W2155467673 @default.
- W2912931895 cites W2622937510 @default.
- W2912931895 cites W2735594299 @default.
- W2912931895 cites W2754860395 @default.
- W2912931895 cites W2758586749 @default.
- W2912931895 cites W2789343877 @default.
- W2912931895 cites W2792098929 @default.
- W2912931895 cites W2792316140 @default.
- W2912931895 cites W2805897237 @default.
- W2912931895 cites W2808218776 @default.
- W2912931895 cites W2810650046 @default.
- W2912931895 cites W2884444148 @default.
- W2912931895 doi "https://doi.org/10.1002/ptr.6279" @default.
- W2912931895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30672024" @default.
- W2912931895 hasPublicationYear "2019" @default.
- W2912931895 type Work @default.
- W2912931895 sameAs 2912931895 @default.
- W2912931895 citedByCount "13" @default.
- W2912931895 countsByYear W29129318952019 @default.
- W2912931895 countsByYear W29129318952020 @default.
- W2912931895 countsByYear W29129318952021 @default.
- W2912931895 countsByYear W29129318952022 @default.
- W2912931895 countsByYear W29129318952023 @default.
- W2912931895 crossrefType "journal-article" @default.
- W2912931895 hasAuthorship W2912931895A5007342889 @default.
- W2912931895 hasAuthorship W2912931895A5026813880 @default.
- W2912931895 hasAuthorship W2912931895A5035417445 @default.
- W2912931895 hasAuthorship W2912931895A5038721765 @default.
- W2912931895 hasAuthorship W2912931895A5044514486 @default.
- W2912931895 hasAuthorship W2912931895A5047114970 @default.
- W2912931895 hasAuthorship W2912931895A5082251390 @default.
- W2912931895 hasAuthorship W2912931895A5085825839 @default.
- W2912931895 hasConcept C125473707 @default.
- W2912931895 hasConcept C126322002 @default.
- W2912931895 hasConcept C141071460 @default.
- W2912931895 hasConcept C142724271 @default.
- W2912931895 hasConcept C204232928 @default.
- W2912931895 hasConcept C204787440 @default.
- W2912931895 hasConcept C27081682 @default.
- W2912931895 hasConcept C2777070074 @default.
- W2912931895 hasConcept C2777230291 @default.
- W2912931895 hasConcept C2778250585 @default.
- W2912931895 hasConcept C2778496288 @default.
- W2912931895 hasConcept C2780159080 @default.
- W2912931895 hasConcept C2780269544 @default.
- W2912931895 hasConcept C2780394083 @default.
- W2912931895 hasConcept C509974204 @default.
- W2912931895 hasConcept C544855455 @default.
- W2912931895 hasConcept C556039675 @default.
- W2912931895 hasConcept C71924100 @default.
- W2912931895 hasConcept C98274493 @default.
- W2912931895 hasConceptScore W2912931895C125473707 @default.
- W2912931895 hasConceptScore W2912931895C126322002 @default.
- W2912931895 hasConceptScore W2912931895C141071460 @default.
- W2912931895 hasConceptScore W2912931895C142724271 @default.
- W2912931895 hasConceptScore W2912931895C204232928 @default.
- W2912931895 hasConceptScore W2912931895C204787440 @default.
- W2912931895 hasConceptScore W2912931895C27081682 @default.
- W2912931895 hasConceptScore W2912931895C2777070074 @default.
- W2912931895 hasConceptScore W2912931895C2777230291 @default.
- W2912931895 hasConceptScore W2912931895C2778250585 @default.
- W2912931895 hasConceptScore W2912931895C2778496288 @default.