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- W2912934522 abstract "Abstract Lantibiotics are a growing class of natural compounds, which possess antimicrobial activity against a broad range of Gram-positive bacteria. Their high potency against human pathogenic strains such as MRSA and VRE makes them excellent candidates as substitutes for classic antibiotics in times of increasing multidrug resistance of bacterial strains. New lantibiotics are detected in genomes and can be heterologously expressed. The functionality of these novel lantibiotics requires a systematic purification and characterization to benchmark them against for example the well-known lantibiotic nisin. Here, we used a standardized workflow to characterize lantibiotics consisting of six individual steps. The expression and secretion of the lantibiotic was performed employing the promiscuous nisin modification machinery. We mutated the first amino acid of nisin into all proteinaceous amino acids and compared their bactericidal potency against sensitive strains as well as strains expressing nisin resistance proteins. Interestingly, we can highlight four distinct groups based on the residual activity of nisin against sensitive as well as resistant L . lactis strains." @default.
- W2912934522 created "2019-02-21" @default.
- W2912934522 creator A5047392065 @default.
- W2912934522 creator A5053722631 @default.
- W2912934522 creator A5075349196 @default.
- W2912934522 creator A5077256764 @default.
- W2912934522 date "2019-01-30" @default.
- W2912934522 modified "2023-09-27" @default.
- W2912934522 title "Systematic characterization of position one variants within the lantibiotic nisin" @default.
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- W2912934522 doi "https://doi.org/10.1038/s41598-018-37532-4" @default.
- W2912934522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6353901" @default.
- W2912934522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30700815" @default.
- W2912934522 hasPublicationYear "2019" @default.
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