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• W2912937049 abstract "Genetically encoded biosensors are useful tools for detecting the presence and levels of diverse biomolecules in living cells. However, low-abundance targets are difficult to detect because they are often unable to bind and activate enough biosensors to detect using standard microscopic imaging approaches. Here we describe a type of RNA-based biosensor, an RNA integrator, which enables detection of low-abundance targets in vitro and in living cells. The RNA integrator is an RNA sequence comprising a ribozyme and an unfolded form of the fluorogenic aptamer Broccoli. Upon binding its target, the ribozyme undergoes cleavage and releases Broccoli, which subsequently folds and becomes fluorescent. Importantly, each target molecule can bind and induce cleavage of multiple copies of the integrator sensor, resulting in an amplified signal. We show that this approach can be generalized to numerous different ribozyme types for the detection of various small molecules." @default.
• W2912937049 created "2019-02-21" @default.
• W2912937049 creator A5005394149 @default.
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• W2912937049 date "2019-04-01" @default.
• W2912937049 modified "2023-10-18" @default.
• W2912937049 title "Detection of Low-Abundance Metabolites in Live Cells Using an RNA Integrator" @default.
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• W2912937049 doi "https://doi.org/10.1016/j.chembiol.2019.01.005" @default.
• W2912937049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6474789" @default.
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