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• W2912940127 startingPage "189" @default.
• W2912940127 abstract "It was evaluated in vitro whether it is possible to induce immunogenicity by haptenization of a nonlymphoid rat tumor, BSp6AS, which is known to be antigenic, but non-immunogenic, in the syngeneic host. The effectivity of 'induced immunogenicity' was tested in vivo. BSp6AS, an NK- and macrophage-resistant variant of a spontaneously arising fibrosarcoma in the BDX rat strain, does not induce a primary or a secondary T cell response after in vivo or in vitro priming. This deficiency in cytotoxic response is due solely to failure of activation of helper T cells (TH), since (a) cytotoxic T cells (CTL) can be detected after in vitro stimulation in the presence of interleukin 2 (IL-2)-containing medium; and (b) there are no indications for down-regulation of a potential specific immune response by suppressor T cells (TS). The lack of activation of tumor-specific TH can be bypassed by activation of hapten-specific TH. Upon coculture with haptenized tumor cells as a stimulator population, both hapten-specific and tumor-specific CTL are activated by hapten-specific TH. In line with the findings in vitro, no transplant rejection of naive tumor cells was seen after a variety of immunization schedules. But immunized F1 hybrids did reject tumor grafts, supporting the hypothesis of lacking help in the syngeneic situation. This could be confirmed in the syngeneic system by adoptive transfer experiments. Tumor-specific CTL, educated in vitro in the presence of IL-2, were ineffective. But complete protection against haptenized, and partial protection against native tumor cells was achieved in the additional presence of hapten-specific TH. To our knowledge these experiments prove for the first time that hapten-specific TH are efficient in inducing an immune response even against a nonlymphoid, nonimmunogenic tumor, i.e., it is possible (a) to activate tumor-specific CTL and (b) to initiate tumor graft rejection via hapten-specific TH." @default.
• W2912940127 created "2019-02-21" @default.
• W2912940127 creator A5039406779 @default.
• W2912940127 date "1985-06-01" @default.
• W2912940127 modified "2023-10-16" @default.
• W2912940127 title "Evaluation of in vivo and in vitro effectivity of immune defense against a spontaneously arising, nonlymphoid rat tumor" @default.
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• W2912940127 doi "https://doi.org/10.1007/bf00199225" @default.
• W2912940127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2408743" @default.
• W2912940127 hasPublicationYear "1985" @default.
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