FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912946036> ?p ?o ?g. }

• W2912946036 endingPage "57" @default.
• W2912946036 startingPage "50" @default.
• W2912946036 abstract "Aim of investigation. To carry out comparative analysis of diagnostic sensitivity of three immunochemical stool tests as a first step of laboratory algorithm to define high risk groups for colorectal cancer (CRC) and other clinically severe diseases of gastrointestinal tract (GIT). Material and methods. Content of hHb, hHb/ Hp and fTu M2-PK was investigated by solid-phase immunoenzyme tests in stool samples of 447 patients: 157 primary CRC cases, 121 stomach cancer (SC) patients, 64 ulcerative colitis (UC), 20 colonic polyps (CP) patients and 85 healthy donors. Following cut off levels were used: hHb - 2,0 µg/mL, hHb/Hp - 0,5 µg/ mL and fTu M2-PK - 4,0 U/mL. Results. The test systems for hHb and hHb/Hp in stool had high sensitivity, that was similar for CRC (89.5% of and of 87.9%, respectively) and UC (79.0% of and of 71.9%). The rate of exceeding upper thresholds for hHb and hHb/Hp in SC patients was 51.2 and 43.8%, respectively, and only 20% for CP patients. hHb and hHb/Hp markers had high specificity for healthy donors (95.3% of and of 97.6%, respectively). Close correlation between hHb and hHb/Hp indicates that these tests are interchangeable for CRC diagnostics. fTu M2-PK sensitivity was 79.2% for CRC, 68.3% - for UC, 51.2% - for SC and fTu M2-PK-specificity was 94.7% as compared to donors. If elevation of at least one marker in a pair (hHb and fTu M2-PK) will be considered as positivity of the test overall, the sensitivity of laboratory testing rises for CRC to 95.0%, for UC - to 83.6% and for SC - to 69.0% at specificity of 91.3%. Conclusions. Comparative analysis of three stool tests (hHb, hHb/Hp and fTu M2-PK) has shown that the optimal combination for detection of CRC risk groups includes detection of fecal hHb and fTu M2-PK. Increase of at least one marker in this pair may be due to the presence of severe gastrointestinal disease, including CRC, that allows to select patient for subsequent investigation of the digestive system. Key words: colorectal cancer, stomach cancer, ulcerative colitis, colonic polyps, fecal immunochemical test (FIT), hHb, hHb/Hp, fTu M2-PK." @default.
• W2912946036 created "2019-02-21" @default.
• W2912946036 creator A5038125883 @default.
• W2912946036 creator A5074567345 @default.
• W2912946036 creator A5079690744 @default.
• W2912946036 date "2016-08-12" @default.
• W2912946036 modified "2023-10-16" @default.
• W2912946036 title "Stool immunoassay for identification of colorectal cancer and other significant gastrointestinal diseases risk groups" @default.
• W2912946036 cites W14875652 @default.
• W2912946036 cites W1494895690 @default.
• W2912946036 cites W2000537355 @default.
• W2912946036 cites W2001502591 @default.
• W2912946036 cites W2028841256 @default.
• W2912946036 cites W2068581079 @default.
• W2912946036 cites W2094768394 @default.
• W2912946036 cites W2097680546 @default.
• W2912946036 cites W2154475664 @default.
• W2912946036 cites W2159239310 @default.
• W2912946036 cites W2401051657 @default.
• W2912946036 doi "https://doi.org/10.22416/1382-4376-2016-26-2-50-57" @default.
• W2912946036 hasPublicationYear "2016" @default.
• W2912946036 type Work @default.
• W2912946036 sameAs 2912946036 @default.
• W2912946036 citedByCount "0" @default.
• W2912946036 crossrefType "journal-article" @default.
• W2912946036 hasAuthorship W2912946036A5038125883 @default.
• W2912946036 hasAuthorship W2912946036A5074567345 @default.
• W2912946036 hasAuthorship W2912946036A5079690744 @default.
• W2912946036 hasBestOaLocation W29129460361 @default.
• W2912946036 hasConcept C116834253 @default.
• W2912946036 hasConcept C121608353 @default.
• W2912946036 hasConcept C126322002 @default.
• W2912946036 hasConcept C143998085 @default.
• W2912946036 hasConcept C159654299 @default.
• W2912946036 hasConcept C203014093 @default.
• W2912946036 hasConcept C2780420688 @default.
• W2912946036 hasConcept C526805850 @default.
• W2912946036 hasConcept C542804219 @default.
• W2912946036 hasConcept C59822182 @default.
• W2912946036 hasConcept C71924100 @default.
• W2912946036 hasConcept C86803240 @default.
• W2912946036 hasConcept C90924648 @default.
• W2912946036 hasConceptScore W2912946036C116834253 @default.
• W2912946036 hasConceptScore W2912946036C121608353 @default.
• W2912946036 hasConceptScore W2912946036C126322002 @default.
• W2912946036 hasConceptScore W2912946036C143998085 @default.
• W2912946036 hasConceptScore W2912946036C159654299 @default.
• W2912946036 hasConceptScore W2912946036C203014093 @default.
• W2912946036 hasConceptScore W2912946036C2780420688 @default.
• W2912946036 hasConceptScore W2912946036C526805850 @default.
• W2912946036 hasConceptScore W2912946036C542804219 @default.
• W2912946036 hasConceptScore W2912946036C59822182 @default.
• W2912946036 hasConceptScore W2912946036C71924100 @default.
• W2912946036 hasConceptScore W2912946036C86803240 @default.
• W2912946036 hasConceptScore W2912946036C90924648 @default.
• W2912946036 hasIssue "2" @default.
• W2912946036 hasLocation W29129460361 @default.
• W2912946036 hasOpenAccess W2912946036 @default.
• W2912946036 hasPrimaryLocation W29129460361 @default.
• W2912946036 hasRelatedWork W134396366 @default.
• W2912946036 hasRelatedWork W1839167940 @default.
• W2912946036 hasRelatedWork W2155078208 @default.
• W2912946036 hasRelatedWork W2363413836 @default.
• W2912946036 hasRelatedWork W2366058936 @default.
• W2912946036 hasRelatedWork W2392730113 @default.
• W2912946036 hasRelatedWork W2412701647 @default.
• W2912946036 hasRelatedWork W2418548021 @default.
• W2912946036 hasRelatedWork W2473759769 @default.
• W2912946036 hasRelatedWork W3004259476 @default.
• W2912946036 hasVolume "26" @default.
• W2912946036 isParatext "false" @default.
• W2912946036 isRetracted "false" @default.
• W2912946036 magId "2912946036" @default.
• W2912946036 workType "article" @default.