Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912953959> ?p ?o ?g. }
- W2912953959 abstract "ABSTRACT The scarcity of embryonic/foetal material as a resource for direct study means that there is still limited understanding of human retina development. Here, we present an integrated transcriptome analysis combined with immunohistochemistry in human eye and retinal samples from 4 to 19 post-conception weeks. This analysis reveals three developmental windows with specific gene expression patterns that informed the sequential emergence of retinal cell types and enabled identification of stage-specific cellular and biological processes, and transcriptional regulators. Each stage is characterised by a specific set of alternatively spliced transcripts that code for proteins involved in the formation of the photoreceptor connecting cilium, pre-mRNA splicing and epigenetic modifiers. Importantly, our data show that the transition from foetal to adult retina is characterised by a large increase in the percentage of mutually exclusive exons that code for proteins involved in photoreceptor maintenance. The circular RNA population is also defined and shown to increase during retinal development. Collectively, these data increase our understanding of human retinal development and the pre-mRNA splicing process, and help to identify new candidate disease genes." @default.
- W2912953959 created "2019-02-21" @default.
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- W2912953959 date "2019-01-15" @default.
- W2912953959 modified "2023-10-17" @default.
- W2912953959 title "An integrated transcriptional analysis of the developing human retina" @default.
- W2912953959 cites W1523279756 @default.
- W2912953959 cites W1555080212 @default.
- W2912953959 cites W1566841623 @default.
- W2912953959 cites W1764005853 @default.
- W2912953959 cites W1777808916 @default.
- W2912953959 cites W1833099573 @default.
- W2912953959 cites W1881148963 @default.
- W2912953959 cites W1918208125 @default.
- W2912953959 cites W1960721561 @default.
- W2912953959 cites W1966411071 @default.
- W2912953959 cites W1967791012 @default.
- W2912953959 cites W1967845403 @default.
- W2912953959 cites W1972071338 @default.
- W2912953959 cites W1975389085 @default.
- W2912953959 cites W1976834260 @default.
- W2912953959 cites W1985912987 @default.
- W2912953959 cites W1988939522 @default.
- W2912953959 cites W1990975890 @default.
- W2912953959 cites W1991082489 @default.
- W2912953959 cites W1991250133 @default.
- W2912953959 cites W1997956353 @default.
- W2912953959 cites W2001504871 @default.
- W2912953959 cites W2001949196 @default.
- W2912953959 cites W2005943162 @default.
- W2912953959 cites W2006377024 @default.
- W2912953959 cites W2014102658 @default.
- W2912953959 cites W2016125390 @default.
- W2912953959 cites W2018931249 @default.
- W2912953959 cites W2019071873 @default.
- W2912953959 cites W2023139734 @default.
- W2912953959 cites W2023506303 @default.
- W2912953959 cites W2027555661 @default.
- W2912953959 cites W2027857932 @default.
- W2912953959 cites W2035618305 @default.
- W2912953959 cites W2041748359 @default.
- W2912953959 cites W2042378303 @default.
- W2912953959 cites W2044453504 @default.
- W2912953959 cites W2047213214 @default.
- W2912953959 cites W2051099456 @default.
- W2912953959 cites W2054677853 @default.
- W2912953959 cites W2054891772 @default.
- W2912953959 cites W2058835062 @default.
- W2912953959 cites W2059344357 @default.
- W2912953959 cites W2063037650 @default.
- W2912953959 cites W2064165694 @default.
- W2912953959 cites W2065268734 @default.
- W2912953959 cites W2065594360 @default.
- W2912953959 cites W2066231767 @default.
- W2912953959 cites W2067470032 @default.
- W2912953959 cites W2068260982 @default.
- W2912953959 cites W2075926073 @default.
- W2912953959 cites W2077428235 @default.
- W2912953959 cites W2079504970 @default.
- W2912953959 cites W2080937698 @default.
- W2912953959 cites W2090922624 @default.
- W2912953959 cites W2094799320 @default.
- W2912953959 cites W2102212449 @default.
- W2912953959 cites W2102619694 @default.
- W2912953959 cites W2107281049 @default.
- W2912953959 cites W2107449497 @default.
- W2912953959 cites W2107802984 @default.
- W2912953959 cites W2109373889 @default.
- W2912953959 cites W2110884132 @default.
- W2912953959 cites W2116538057 @default.
- W2912953959 cites W2119244776 @default.
- W2912953959 cites W2126938291 @default.
- W2912953959 cites W2128016314 @default.
- W2912953959 cites W2129174402 @default.
- W2912953959 cites W2129240922 @default.
- W2912953959 cites W2129618668 @default.
- W2912953959 cites W2133481779 @default.
- W2912953959 cites W2143350291 @default.
- W2912953959 cites W2147806662 @default.
- W2912953959 cites W2159438136 @default.
- W2912953959 cites W2159675211 @default.
- W2912953959 cites W2161932769 @default.