FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912954298> ?p ?o ?g. }

• W2912954298 endingPage "742" @default.
• W2912954298 startingPage "742" @default.
• W2912954298 abstract "Mutations in isocitrate dehydrogenase (IDH) or a reduced expression of L-2-hydroxyglutarate (HG)-dehydrogenase result in accumulation of D-2-HG or L-2-HG, respectively, in tumor tissues. D-2-HG and L-2-HG have been shown to affect T-cell differentiation and activation; however, effects on human myeloid cells have not been investigated so far. In this study we analyzed the impact of D-2-HG and L-2-HG on activation and maturation of human monocyte-derived dendritic cells (DCs). 2-HG was taken up by DCs and had no impact on cell viability but diminished CD83 expression after Lipopolysaccharides (LPS) stimulation. Furthermore, D-2-HG and L-2-HG significantly reduced IL-12 secretion but had no impact on other cytokines such as IL-6, IL-10 or TNF. Gene expression analyses of the IL-12 subunits p35/IL-12A and p40/IL-12B in DCs revealed decreased expression of both subunits. Signaling pathways involved in LPS-induced cytokine expression (NFkB, Akt, p38) were not altered by D-2-HG. However, 2-HG reprogrammed LPS-induced metabolic changes in DCs and increased oxygen consumption. Addition of the ATP synthase inhibitor oligomycin to DC cultures increased IL-12 secretion and was able to partially revert the effect of 2-HG. Our data show that both enantiomers of 2-HG can limit activation of DCs in the tumor environment." @default.
• W2912954298 created "2019-02-21" @default.
• W2912954298 creator A5005650529 @default.
• W2912954298 creator A5011580678 @default.
• W2912954298 creator A5021285843 @default.
• W2912954298 creator A5033784534 @default.
• W2912954298 creator A5049728924 @default.
• W2912954298 creator A5059556889 @default.
• W2912954298 creator A5065122812 @default.
• W2912954298 creator A5069736295 @default.
• W2912954298 creator A5071499040 @default.
• W2912954298 creator A5078665930 @default.
• W2912954298 creator A5081082077 @default.
• W2912954298 creator A5081742830 @default.
• W2912954298 creator A5089657026 @default.
• W2912954298 date "2019-02-10" @default.
• W2912954298 modified "2023-10-18" @default.
• W2912954298 title "D-2-Hydroxyglutarate and L-2-Hydroxyglutarate Inhibit IL-12 Secretion by Human Monocyte-Derived Dendritic Cells" @default.
• W2912954298 cites W1486200716 @default.
• W2912954298 cites W1499902555 @default.
• W2912954298 cites W1544249031 @default.
• W2912954298 cites W1661544713 @default.
• W2912954298 cites W1749037810 @default.
• W2912954298 cites W1751327912 @default.
• W2912954298 cites W1831063376 @default.
• W2912954298 cites W1847894796 @default.
• W2912954298 cites W1866233112 @default.
• W2912954298 cites W1980547319 @default.
• W2912954298 cites W1984882020 @default.
• W2912954298 cites W1995116853 @default.
• W2912954298 cites W2000323986 @default.
• W2912954298 cites W2000997280 @default.
• W2912954298 cites W2006540005 @default.
• W2912954298 cites W2012588998 @default.
• W2912954298 cites W2017525816 @default.
• W2912954298 cites W2023702648 @default.
• W2912954298 cites W2030434933 @default.
• W2912954298 cites W2040827479 @default.
• W2912954298 cites W2062936534 @default.
• W2912954298 cites W2066640259 @default.
• W2912954298 cites W2082102301 @default.
• W2912954298 cites W2105699711 @default.
• W2912954298 cites W2114064258 @default.
• W2912954298 cites W2115338756 @default.
• W2912954298 cites W2126817554 @default.
• W2912954298 cites W2134061682 @default.
• W2912954298 cites W2142300779 @default.
• W2912954298 cites W2155800445 @default.
• W2912954298 cites W2327145944 @default.
• W2912954298 cites W2407131888 @default.
• W2912954298 cites W2418211263 @default.
• W2912954298 cites W2460918282 @default.
• W2912954298 cites W251776763 @default.
• W2912954298 cites W2519020116 @default.
• W2912954298 cites W2537440061 @default.
• W2912954298 cites W2592164001 @default.
• W2912954298 cites W2594575075 @default.
• W2912954298 cites W2596261790 @default.
• W2912954298 cites W2615603032 @default.
• W2912954298 cites W2790027255 @default.
• W2912954298 cites W2808730110 @default.
• W2912954298 cites W2878436114 @default.
• W2912954298 doi "https://doi.org/10.3390/ijms20030742" @default.
• W2912954298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6387367" @default.
• W2912954298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30744183" @default.
• W2912954298 hasPublicationYear "2019" @default.
• W2912954298 type Work @default.
• W2912954298 sameAs 2912954298 @default.
• W2912954298 citedByCount "12" @default.
• W2912954298 countsByYear W29129542982019 @default.
• W2912954298 countsByYear W29129542982020 @default.
• W2912954298 countsByYear W29129542982021 @default.
• W2912954298 countsByYear W29129542982022 @default.
• W2912954298 crossrefType "journal-article" @default.
• W2912954298 hasAuthorship W2912954298A5005650529 @default.
• W2912954298 hasAuthorship W2912954298A5011580678 @default.
• W2912954298 hasAuthorship W2912954298A5021285843 @default.
• W2912954298 hasAuthorship W2912954298A5033784534 @default.
• W2912954298 hasAuthorship W2912954298A5049728924 @default.
• W2912954298 hasAuthorship W2912954298A5059556889 @default.
• W2912954298 hasAuthorship W2912954298A5065122812 @default.
• W2912954298 hasAuthorship W2912954298A5069736295 @default.
• W2912954298 hasAuthorship W2912954298A5071499040 @default.
• W2912954298 hasAuthorship W2912954298A5078665930 @default.
• W2912954298 hasAuthorship W2912954298A5081082077 @default.
• W2912954298 hasAuthorship W2912954298A5081742830 @default.
• W2912954298 hasAuthorship W2912954298A5089657026 @default.
• W2912954298 hasBestOaLocation W29129542981 @default.
• W2912954298 hasConcept C153911025 @default.
• W2912954298 hasConcept C185592680 @default.
• W2912954298 hasConcept C203014093 @default.
• W2912954298 hasConcept C2778170410 @default.
• W2912954298 hasConcept C2778690821 @default.
• W2912954298 hasConcept C2781184567 @default.
• W2912954298 hasConcept C49039625 @default.
• W2912954298 hasConcept C55493867 @default.
• W2912954298 hasConcept C86803240 @default.
• W2912954298 hasConcept C8891405 @default.

• next