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- W2912962312 endingPage "16" @default.
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- W2912962312 abstract "Plasmodium falciparum histone deacetylases (PfHDACs) are an important class of epigenetic regulators that alter protein lysine acetylation, contributing to regulation of gene expression and normal parasite growth and development. PfHDACs are therefore under investigation as drug targets for malaria. Despite this, our understanding of the biological roles of these enzymes is only just beginning to emerge. In higher eukaryotes, HDACs function as part of multi-protein complexes and act on both histone and non-histone substrates. Here, we present a proteomics analysis of PfHDAC1 immunoprecipitates, identifying 26 putative P. falciparum complex proteins in trophozoite-stage asexual intraerythrocytic parasites. The co-migration of two of these (P. falciparum heat shock proteins 70-1 and 90) with PfHDAC1 was validated using Blue Native PAGE combined with Western blot. These data provide a snapshot of possible PfHDAC1 interactions and a starting point for future studies focused on elucidating the broader function of PfHDACs in Plasmodium parasites." @default.
- W2912962312 created "2019-02-21" @default.
- W2912962312 creator A5014383684 @default.
- W2912962312 creator A5015105620 @default.
- W2912962312 creator A5017617402 @default.
- W2912962312 creator A5044047627 @default.
- W2912962312 creator A5045330865 @default.
- W2912962312 creator A5055545983 @default.
- W2912962312 creator A5056872315 @default.
- W2912962312 creator A5062778164 @default.
- W2912962312 creator A5069743870 @default.
- W2912962312 creator A5084779683 @default.
- W2912962312 date "2019-03-01" @default.
- W2912962312 modified "2023-09-26" @default.
- W2912962312 title "Proteomic analysis of Plasmodium falciparum histone deacetylase 1 complex proteins" @default.
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