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• W2912963101 abstract "THE RADIOSENSITIVITY of the skin can be altered as a result of physiological status or external manipulation before, during, or after exposure to radiation. Alteration of skin temperature, concurrent with irradiation, is the most frequently reported method of modifying the sensitivity of the skin by objective measures (1–3). There is not, however, complete agreement among investigators in respect to the effect of altering the temperature of the skin (4–6). In 1960 our group reported a quantitative measure of skin change of both erythema and melanin formation, utilizing the reflectance spectrophotometer (7, 8). In view of the variation of observations of modification of radiation injury to human skin, the present study was undertaken in the hope that by employing this standardized quantitative technic the problem might be clarified. Materials And Methods Volunteer patients undergoing treatment for malignant disease were selected for this investigation. To explore the possibility that the pattern of events might be modified by a difference in melanin content of the skin, both Negro and white patients were participants. The areas under study were never involved in the neoplastic process or the treatment thereof. After defining three adjacent areas on the anterior aspect of both thighs of each patient, base-line values for oxyhemoglobin, reduced hemoglobin, and melanin content were determined, using the reflectance spectrophotometer. Of the three areas on each limb the center received no radiation, one was irradiated at normal temperature, and the remaining one was irradiated at either increased or decreased temperature (Fig. 1). Additionally, an independent area was selected on the arm and similarly measured to serve as an indicator of any abnormal behavior of the skin capillaries or of the dermis in general. The skin temperature was modified by circulating hot, cold, or ambient temperature water through a Lucite box in direct contact with the area to be irradiated. The temperature of the water was maintained by a thermostatically controlled heating coil attached to the pump. A Thermistor-thermometer with a hypodermic probe was employed to ascertain the temperature of the area to be irradiated (Fig. 2). The probe was inserted 2 to 3 mm beneath the surface of the skin. The procedure was easily tolerated by the patients after an initial injection of Xylo-caine at the point of insertion of the probe. In Part I of this study, in which seven patients participated, the degree range for the increased temperature was 40.5 to 44.5° C and for the decreased temperature, 8 to 18° C. When the highest tolerable or the lowest attainable temperatures had been maintained for ten minutes the area was irradiated. Once the exposure was completed, the probe was removed and the area permitted to return to normal temperature." @default.
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• W2912963101 date "1966-11-01" @default.
• W2912963101 modified "2023-09-26" @default.
• W2912963101 title "Quantitative and Qualitative Evaluation of Skin Erythema" @default.
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• W2912963101 doi "https://doi.org/10.1148/87.5.916" @default.
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