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- W2912968058 abstract "In the absence of an effective vaccine, alternative approaches to block HIV-1 infection and transmission with commensal bacteria expressing antiviral proteins are being considered. This report provides a proof-of-concept by using Lactobacillus bacteria stably expressing the HIV-1 receptor CD4 to capture and neutralize HIV-1 in vitro and in a humanized mouse model. The stable expression of antiviral proteins, such as CD4, following genomic integration of the corresponding genes into this Lactobacillus strain may contribute to the prevention of HIV-1 sexual transmission." @default.
- W2912968058 created "2019-02-21" @default.
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- W2912968058 date "2019-04-15" @default.
- W2912968058 modified "2023-09-28" @default.
- W2912968058 title "Blocking HIV-1 Infection by Chromosomal Integrative Expression of Human CD4 on the Surface of Lactobacillus acidophilus ATCC 4356" @default.
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- W2912968058 doi "https://doi.org/10.1128/jvi.01830-18" @default.
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