Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912973551> ?p ?o ?g. }
- W2912973551 endingPage "531" @default.
- W2912973551 startingPage "522" @default.
- W2912973551 abstract "Abstract Although most medications can be taken safely during breastfeeding, potential risks of infant toxicity do exist because all medications will be excreted into the breast milk to some extent. The amount of medication excreted in the milk depends mainly on (i) within‐drug variation, such as dosing; (ii) between‐drug variation including chemical characteristics of the medication; and (iii) host factors, such as maternal pharmacokinetics (PK), including variations of pregnancy‐associated changes and their post‐partum recovery. Neonatal drug exposure is usually assessed by calculating an expected total infant daily dose through breast milk and comparing it to the normal therapeutic dose. However, clinical PK studies in this population are challenging to conduct. Recently, research methods using population PK analyses and physiologically‐based PK modeling and simulation techniques have been recognized as a complementary approach to the conventional PK studies in this field. These efforts are important for rational risk assessment balancing the toxicity risk against the benefits of human milk. Health benefits of lactation for both mother and child are significant and a decision to withhold from this should not be taken lightly. In case limited information is present, additional expertise from pharmacists or clinical pharmacologist with expertise in this area should be sought." @default.
- W2912973551 created "2019-02-21" @default.
- W2912973551 creator A5033710795 @default.
- W2912973551 creator A5039541971 @default.
- W2912973551 date "2019-01-20" @default.
- W2912973551 modified "2023-10-14" @default.
- W2912973551 title "Drugs in lactation" @default.
- W2912973551 cites W1493547803 @default.
- W2912973551 cites W1522683913 @default.
- W2912973551 cites W1545442835 @default.
- W2912973551 cites W1631592738 @default.
- W2912973551 cites W1656878286 @default.
- W2912973551 cites W1765879118 @default.
- W2912973551 cites W1927322175 @default.
- W2912973551 cites W1963537483 @default.
- W2912973551 cites W1971965087 @default.
- W2912973551 cites W1973062244 @default.
- W2912973551 cites W1978164394 @default.
- W2912973551 cites W1981254809 @default.
- W2912973551 cites W1987988381 @default.
- W2912973551 cites W1990589891 @default.
- W2912973551 cites W1993617813 @default.
- W2912973551 cites W1998362237 @default.
- W2912973551 cites W1998643699 @default.
- W2912973551 cites W1999449749 @default.
- W2912973551 cites W2008430084 @default.
- W2912973551 cites W2023335564 @default.
- W2912973551 cites W2025116305 @default.
- W2912973551 cites W2029965341 @default.
- W2912973551 cites W2033286276 @default.
- W2912973551 cites W2034091997 @default.
- W2912973551 cites W2035115476 @default.
- W2912973551 cites W2037065704 @default.
- W2912973551 cites W2037883570 @default.
- W2912973551 cites W2038195864 @default.
- W2912973551 cites W2039481548 @default.
- W2912973551 cites W2053131910 @default.
- W2912973551 cites W2061037879 @default.
- W2912973551 cites W2065150571 @default.
- W2912973551 cites W2065920376 @default.
- W2912973551 cites W2074576600 @default.
- W2912973551 cites W2081344246 @default.
- W2912973551 cites W2082424110 @default.
- W2912973551 cites W2085981001 @default.
- W2912973551 cites W2087448902 @default.
- W2912973551 cites W2103977981 @default.
- W2912973551 cites W2104837622 @default.
- W2912973551 cites W2111518340 @default.
- W2912973551 cites W2114542242 @default.
- W2912973551 cites W2120018440 @default.
- W2912973551 cites W2122527560 @default.
- W2912973551 cites W2124448589 @default.
- W2912973551 cites W2129970152 @default.
- W2912973551 cites W2131363475 @default.
- W2912973551 cites W2131882241 @default.
- W2912973551 cites W2132504508 @default.
- W2912973551 cites W2136501202 @default.
- W2912973551 cites W2138677572 @default.
- W2912973551 cites W2139888809 @default.
- W2912973551 cites W2140952865 @default.
- W2912973551 cites W2142606427 @default.
- W2912973551 cites W2147105948 @default.
- W2912973551 cites W2153653511 @default.
- W2912973551 cites W2159769493 @default.
- W2912973551 cites W2167447926 @default.
- W2912973551 cites W2167719357 @default.
- W2912973551 cites W2238635333 @default.
- W2912973551 cites W2267159071 @default.
- W2912973551 cites W2270567475 @default.
- W2912973551 cites W2338027690 @default.
- W2912973551 cites W2339438533 @default.
- W2912973551 cites W2413350779 @default.
- W2912973551 cites W2491551754 @default.
- W2912973551 cites W2521991879 @default.
- W2912973551 cites W2547067825 @default.
- W2912973551 cites W2589699200 @default.
- W2912973551 cites W2622443792 @default.
- W2912973551 cites W2749869614 @default.
- W2912973551 cites W2766360078 @default.
- W2912973551 cites W2768613862 @default.
- W2912973551 cites W2783725520 @default.
- W2912973551 cites W2793509133 @default.
- W2912973551 cites W2794281539 @default.
- W2912973551 cites W2886931759 @default.
- W2912973551 cites W2888635470 @default.
- W2912973551 cites W2893109079 @default.
- W2912973551 cites W2895219927 @default.
- W2912973551 cites W4205735253 @default.
- W2912973551 cites W4253487083 @default.
- W2912973551 doi "https://doi.org/10.1111/jog.13899" @default.
- W2912973551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30663176" @default.
- W2912973551 hasPublicationYear "2019" @default.
- W2912973551 type Work @default.
- W2912973551 sameAs 2912973551 @default.
- W2912973551 citedByCount "18" @default.
- W2912973551 countsByYear W29129735512019 @default.
- W2912973551 countsByYear W29129735512020 @default.
- W2912973551 countsByYear W29129735512021 @default.