Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912974444> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2912974444 endingPage "78" @default.
- W2912974444 startingPage "75" @default.
- W2912974444 abstract "Proton and carbon therapy are the main choices of particle therapy for cancer treatment. Particle dose distribution is superior to conventional photon therapy dose distribution due to Bragg peak. However, the basic biology of cellular damage and cell death is not well understood. The aim of this work is to present a mechanistic model of double strand break (DSB) repair that predicts the repair kinetics of damage induced by particles employed in cancer therapy. Monte Carlo Track Damage Simulation (MCDS) was employed to model DNA damage. The frequency of DSB and SSB was computed for proton and carbon ions. DSBs were subjected to repair model to calculate the repair kinetics. Two distinct DSB repair models dependent on the cell cycle were proposed. The DSB repair model contains non-homologous end joining (NHEJ), homologous recombination (HR) and back up non-homologous end joining (B-NHEJ) repair processes. The DSB complexity results in the switch in the repair pathway from NHEJ to a slower process that starts with DSB end resection. DSB end resection in early S and G1 phases of the cell cycle enhances the B-NHEJ repair pathway, while in late S and G2 phases of the cell cycle promotes HR repair pathway. The repair model was transformed to a set of nonlinear differential equations. The model calculates the overall repair kinetics and protein temporal repair activity at the site of damage. The damage and repair model provides a detailed mechanistic understanding of all processes that are involved in the damage induction and repair. The number of DSB and their complexity increase as the particle energy decreases due to the proximity of particle interactions in water. The repair kinetics show a biphasic behaviour that is due to the NHEJ fast repair of simple type DSB and HR slow repair of complex type DSB." @default.
- W2912974444 created "2019-02-21" @default.
- W2912974444 creator A5032433695 @default.
- W2912974444 date "2019-01-21" @default.
- W2912974444 modified "2023-09-24" @default.
- W2912974444 title "MODELLING DSB REPAIR KINETICS FOR DNA DAMAGE INDUCED BY PROTON AND CARBON IONS" @default.
- W2912974444 cites W1482774800 @default.
- W2912974444 cites W1923055195 @default.
- W2912974444 cites W1964821618 @default.
- W2912974444 cites W1965428130 @default.
- W2912974444 cites W1969396571 @default.
- W2912974444 cites W1974260179 @default.
- W2912974444 cites W1993643627 @default.
- W2912974444 cites W1997817263 @default.
- W2912974444 cites W2016801410 @default.
- W2912974444 cites W2051112666 @default.
- W2912974444 cites W2083079551 @default.
- W2912974444 cites W2083990621 @default.
- W2912974444 cites W2090513228 @default.
- W2912974444 cites W2130759927 @default.
- W2912974444 cites W2139535302 @default.
- W2912974444 cites W2143301911 @default.
- W2912974444 cites W2152042169 @default.
- W2912974444 cites W2165339852 @default.
- W2912974444 cites W2238893464 @default.
- W2912974444 cites W2521134478 @default.
- W2912974444 cites W2580248979 @default.
- W2912974444 doi "https://doi.org/10.1093/rpd/ncy304" @default.
- W2912974444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30668809" @default.
- W2912974444 hasPublicationYear "2019" @default.
- W2912974444 type Work @default.
- W2912974444 sameAs 2912974444 @default.
- W2912974444 citedByCount "6" @default.
- W2912974444 countsByYear W29129744442019 @default.
- W2912974444 countsByYear W29129744442020 @default.
- W2912974444 countsByYear W29129744442021 @default.
- W2912974444 crossrefType "journal-article" @default.
- W2912974444 hasAuthorship W2912974444A5032433695 @default.
- W2912974444 hasConcept C102744134 @default.
- W2912974444 hasConcept C122917832 @default.
- W2912974444 hasConcept C12554922 @default.
- W2912974444 hasConcept C134935766 @default.
- W2912974444 hasConcept C143425029 @default.
- W2912974444 hasConcept C1491633281 @default.
- W2912974444 hasConcept C185592680 @default.
- W2912974444 hasConcept C29537977 @default.
- W2912974444 hasConcept C552990157 @default.
- W2912974444 hasConcept C55493867 @default.
- W2912974444 hasConcept C86803240 @default.
- W2912974444 hasConceptScore W2912974444C102744134 @default.
- W2912974444 hasConceptScore W2912974444C122917832 @default.
- W2912974444 hasConceptScore W2912974444C12554922 @default.
- W2912974444 hasConceptScore W2912974444C134935766 @default.
- W2912974444 hasConceptScore W2912974444C143425029 @default.
- W2912974444 hasConceptScore W2912974444C1491633281 @default.
- W2912974444 hasConceptScore W2912974444C185592680 @default.
- W2912974444 hasConceptScore W2912974444C29537977 @default.
- W2912974444 hasConceptScore W2912974444C552990157 @default.
- W2912974444 hasConceptScore W2912974444C55493867 @default.
- W2912974444 hasConceptScore W2912974444C86803240 @default.
- W2912974444 hasIssue "1-2" @default.
- W2912974444 hasLocation W29129744441 @default.
- W2912974444 hasLocation W29129744442 @default.
- W2912974444 hasOpenAccess W2912974444 @default.
- W2912974444 hasPrimaryLocation W29129744441 @default.
- W2912974444 hasRelatedWork W1780348968 @default.
- W2912974444 hasRelatedWork W2016949934 @default.
- W2912974444 hasRelatedWork W2026518361 @default.
- W2912974444 hasRelatedWork W2076951953 @default.
- W2912974444 hasRelatedWork W2135397815 @default.
- W2912974444 hasRelatedWork W2161452450 @default.
- W2912974444 hasRelatedWork W2294323102 @default.
- W2912974444 hasRelatedWork W2736937294 @default.
- W2912974444 hasRelatedWork W3040777022 @default.
- W2912974444 hasRelatedWork W3178716637 @default.
- W2912974444 hasVolume "183" @default.
- W2912974444 isParatext "false" @default.
- W2912974444 isRetracted "false" @default.
- W2912974444 magId "2912974444" @default.
- W2912974444 workType "article" @default.