FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912976592> ?p ?o ?g. }

• W2912976592 endingPage "222" @default.
• W2912976592 startingPage "210" @default.
• W2912976592 abstract "Insulin resistance is thought to be a common link between obesity and Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD has now reached epidemic status worldwide and identification of molecules or pathways as newer therapeutic strategies either to prevent or overcome insulin resistance seems critical. Dysregulated hepatic lipogenesis (DNL) is a hallmark of NAFLD in humans and rodents. Therefore, reducing DNL accretion may be critical in the development of therapeutics of NAFLD. In our in vivo model (high-fat-diet fed [HFD] obese mice) we found Zinc oxide nanoparticles (ZnO NPs) significantly decreased HFD-induced hepatic steatosis and peripheral insulin resistance. This protective mechanism of ZnO NPs was signaled through hepatic SIRT1-LKB1-AMPK which restricted SREBP-1c within the cytosol limiting its transcriptional ability and thereby ameliorating HFD mediated DNL. These observations indicate that ZnO NP can serve as a therapeutic strategy to improve the physiological homeostasis during obesity and its associated metabolic abnormalities." @default.
• W2912976592 created "2019-02-21" @default.
• W2912976592 creator A5018083966 @default.
• W2912976592 creator A5018948305 @default.
• W2912976592 creator A5038232903 @default.
• W2912976592 creator A5050192311 @default.
• W2912976592 creator A5051683973 @default.
• W2912976592 creator A5062596336 @default.
• W2912976592 creator A5066754608 @default.
• W2912976592 creator A5067526941 @default.
• W2912976592 creator A5079314391 @default.
• W2912976592 creator A5083907457 @default.
• W2912976592 date "2019-04-01" @default.
• W2912976592 modified "2023-10-09" @default.
• W2912976592 title "Zinc oxide nanoparticles attenuate hepatic steatosis development in high-fat-diet fed mice through activated AMPK signaling axis" @default.
• W2912976592 cites W1967717006 @default.
• W2912976592 cites W1973163466 @default.
• W2912976592 cites W1974474968 @default.
• W2912976592 cites W1976159941 @default.
• W2912976592 cites W1985241942 @default.
• W2912976592 cites W1998265194 @default.
• W2912976592 cites W2005430088 @default.
• W2912976592 cites W2007809519 @default.
• W2912976592 cites W2011574523 @default.
• W2912976592 cites W2028782957 @default.
• W2912976592 cites W2032878070 @default.
• W2912976592 cites W2035816889 @default.
• W2912976592 cites W2040109162 @default.
• W2912976592 cites W2045333877 @default.
• W2912976592 cites W2065788704 @default.
• W2912976592 cites W2067570070 @default.
• W2912976592 cites W2090063543 @default.
• W2912976592 cites W2091330563 @default.
• W2912976592 cites W2092340120 @default.
• W2912976592 cites W2107333702 @default.
• W2912976592 cites W2117716768 @default.
• W2912976592 cites W2140467079 @default.
• W2912976592 cites W2149785020 @default.
• W2912976592 cites W2153227525 @default.
• W2912976592 cites W2230222215 @default.
• W2912976592 cites W2291173445 @default.
• W2912976592 cites W2529803834 @default.
• W2912976592 doi "https://doi.org/10.1016/j.nano.2019.01.013" @default.
• W2912976592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30708053" @default.
• W2912976592 hasPublicationYear "2019" @default.
• W2912976592 type Work @default.
• W2912976592 sameAs 2912976592 @default.
• W2912976592 citedByCount "23" @default.
• W2912976592 countsByYear W29129765922019 @default.
• W2912976592 countsByYear W29129765922020 @default.
• W2912976592 countsByYear W29129765922021 @default.
• W2912976592 countsByYear W29129765922022 @default.
• W2912976592 countsByYear W29129765922023 @default.
• W2912976592 crossrefType "journal-article" @default.
• W2912976592 hasAuthorship W2912976592A5018083966 @default.
• W2912976592 hasAuthorship W2912976592A5018948305 @default.
• W2912976592 hasAuthorship W2912976592A5038232903 @default.
• W2912976592 hasAuthorship W2912976592A5050192311 @default.
• W2912976592 hasAuthorship W2912976592A5051683973 @default.
• W2912976592 hasAuthorship W2912976592A5062596336 @default.
• W2912976592 hasAuthorship W2912976592A5066754608 @default.
• W2912976592 hasAuthorship W2912976592A5067526941 @default.
• W2912976592 hasAuthorship W2912976592A5079314391 @default.
• W2912976592 hasAuthorship W2912976592A5083907457 @default.
• W2912976592 hasConcept C126322002 @default.
• W2912976592 hasConcept C134018914 @default.
• W2912976592 hasConcept C141359234 @default.
• W2912976592 hasConcept C171089720 @default.
• W2912976592 hasConcept C184235292 @default.
• W2912976592 hasConcept C2776175330 @default.
• W2912976592 hasConcept C2777391703 @default.
• W2912976592 hasConcept C2778772119 @default.
• W2912976592 hasConcept C2779134260 @default.
• W2912976592 hasConcept C2779306644 @default.
• W2912976592 hasConcept C2780124434 @default.
• W2912976592 hasConcept C71924100 @default.
• W2912976592 hasConcept C86803240 @default.
• W2912976592 hasConcept C95444343 @default.
• W2912976592 hasConcept C97029542 @default.
• W2912976592 hasConceptScore W2912976592C126322002 @default.
• W2912976592 hasConceptScore W2912976592C134018914 @default.
• W2912976592 hasConceptScore W2912976592C141359234 @default.
• W2912976592 hasConceptScore W2912976592C171089720 @default.
• W2912976592 hasConceptScore W2912976592C184235292 @default.
• W2912976592 hasConceptScore W2912976592C2776175330 @default.
• W2912976592 hasConceptScore W2912976592C2777391703 @default.
• W2912976592 hasConceptScore W2912976592C2778772119 @default.
• W2912976592 hasConceptScore W2912976592C2779134260 @default.
• W2912976592 hasConceptScore W2912976592C2779306644 @default.
• W2912976592 hasConceptScore W2912976592C2780124434 @default.
• W2912976592 hasConceptScore W2912976592C71924100 @default.
• W2912976592 hasConceptScore W2912976592C86803240 @default.
• W2912976592 hasConceptScore W2912976592C95444343 @default.
• W2912976592 hasConceptScore W2912976592C97029542 @default.
• W2912976592 hasFunder F4320334771 @default.
• W2912976592 hasLocation W29129765921 @default.
• W2912976592 hasLocation W29129765922 @default.
• W2912976592 hasOpenAccess W2912976592 @default.

• next