Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912986113> ?p ?o ?g. }
- W2912986113 endingPage "97" @default.
- W2912986113 startingPage "86" @default.
- W2912986113 abstract "Shisha (water pipe) smoking is falsely believed to be a hazard-free habit and has become a major public health concern. Studies have reported shisha smoking to be associated with oral lesions, as well as carcinomas of the lung, esophagus, bladder, and pancreas. A deeper understanding of the underlying molecular mechanisms would contribute to identification of biomarkers for targeted public health screening, therapeutic innovation, and better prognosis of associated diseases. In this study, we have established an in vitro chronic cellular model of shisha-exposed oral keratinocytes to study the effect of shisha on oral cells. Normal nontransformed, immortalized oral keratinocytes were chronically exposed to shisha extract for 8 months. This resulted in significant increase in cellular proliferation and cell invasion in shisha-exposed cells compared to the parental cells. Quantitative proteomic analysis of OKF6/TERT1-Parental and OKF6/TERT1-Shisha cells resulted in the identification of 5515 proteins. Forty-three differentially expressed proteins were found to be common across all conditions. Bioinformatic analysis of the dysregulated proteins identified in the proteomic study revealed dysregulation of interferon pathway, upregulation of proteins involved in cell growth, and downregulation of immune processes. The present findings reveal that chronic exposure of normal oral keratinocytes to shisha leads to cellular transformation and dysregulation of immune response. To the best of our knowledge, this is the first report that has developed a model of oral keratinocytes chronically exposed to shisha and identified proteomic alterations associated with shisha exposure. However, further research is required to evaluate the health burden of shisha smoking." @default.
- W2912986113 created "2019-02-21" @default.
- W2912986113 creator A5008363488 @default.
- W2912986113 creator A5009531133 @default.
- W2912986113 creator A5017187757 @default.
- W2912986113 creator A5018455558 @default.
- W2912986113 creator A5022145157 @default.
- W2912986113 creator A5035455861 @default.
- W2912986113 creator A5036906888 @default.
- W2912986113 creator A5037945413 @default.
- W2912986113 creator A5039599940 @default.
- W2912986113 creator A5049209796 @default.
- W2912986113 creator A5053247947 @default.
- W2912986113 creator A5062149446 @default.
- W2912986113 creator A5067908401 @default.
- W2912986113 creator A5089664025 @default.
- W2912986113 date "2019-02-01" @default.
- W2912986113 modified "2023-09-23" @default.
- W2912986113 title "Proteomic Changes in Oral Keratinocytes Chronically Exposed to Shisha (Water Pipe)" @default.
- W2912986113 cites W1797058518 @default.
- W2912986113 cites W1832212699 @default.
- W2912986113 cites W1859326932 @default.
- W2912986113 cites W1964925501 @default.
- W2912986113 cites W1970672489 @default.
- W2912986113 cites W1972814371 @default.
- W2912986113 cites W1987589866 @default.
- W2912986113 cites W1988720219 @default.
- W2912986113 cites W1989194356 @default.
- W2912986113 cites W1994821015 @default.
- W2912986113 cites W1995407474 @default.
- W2912986113 cites W1998015616 @default.
- W2912986113 cites W2005614299 @default.
- W2912986113 cites W2020148863 @default.
- W2912986113 cites W2040401741 @default.
- W2912986113 cites W2048351247 @default.
- W2912986113 cites W2059641771 @default.
- W2912986113 cites W2072759972 @default.
- W2912986113 cites W2081263700 @default.
- W2912986113 cites W2086338082 @default.
- W2912986113 cites W2095106782 @default.
- W2912986113 cites W2110519384 @default.
- W2912986113 cites W2117519651 @default.
- W2912986113 cites W2119696300 @default.
- W2912986113 cites W2126314905 @default.
- W2912986113 cites W2129582750 @default.
- W2912986113 cites W2135422535 @default.
- W2912986113 cites W2135581618 @default.
- W2912986113 cites W2161465168 @default.
- W2912986113 cites W2167230824 @default.
- W2912986113 cites W2169174909 @default.
- W2912986113 cites W2185536407 @default.
- W2912986113 cites W2201057556 @default.
- W2912986113 cites W2285621780 @default.
- W2912986113 cites W2335902060 @default.
- W2912986113 cites W2402565541 @default.
- W2912986113 cites W2463195069 @default.
- W2912986113 cites W2535284666 @default.
- W2912986113 cites W2535385744 @default.
- W2912986113 cites W2559756887 @default.
- W2912986113 cites W2602655635 @default.
- W2912986113 cites W2605968798 @default.
- W2912986113 cites W2770963529 @default.
- W2912986113 cites W2783808413 @default.
- W2912986113 cites W2793884173 @default.
- W2912986113 cites W2795269319 @default.
- W2912986113 cites W2802756113 @default.
- W2912986113 cites W2802807862 @default.
- W2912986113 cites W4232534952 @default.
- W2912986113 doi "https://doi.org/10.1089/omi.2018.0173" @default.
- W2912986113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30767727" @default.
- W2912986113 hasPublicationYear "2019" @default.
- W2912986113 type Work @default.
- W2912986113 sameAs 2912986113 @default.
- W2912986113 citedByCount "7" @default.
- W2912986113 countsByYear W29129861132019 @default.
- W2912986113 countsByYear W29129861132020 @default.
- W2912986113 countsByYear W29129861132021 @default.
- W2912986113 countsByYear W29129861132022 @default.
- W2912986113 countsByYear W29129861132023 @default.
- W2912986113 crossrefType "journal-article" @default.
- W2912986113 hasAuthorship W2912986113A5008363488 @default.
- W2912986113 hasAuthorship W2912986113A5009531133 @default.
- W2912986113 hasAuthorship W2912986113A5017187757 @default.
- W2912986113 hasAuthorship W2912986113A5018455558 @default.
- W2912986113 hasAuthorship W2912986113A5022145157 @default.
- W2912986113 hasAuthorship W2912986113A5035455861 @default.
- W2912986113 hasAuthorship W2912986113A5036906888 @default.
- W2912986113 hasAuthorship W2912986113A5037945413 @default.
- W2912986113 hasAuthorship W2912986113A5039599940 @default.
- W2912986113 hasAuthorship W2912986113A5049209796 @default.
- W2912986113 hasAuthorship W2912986113A5053247947 @default.
- W2912986113 hasAuthorship W2912986113A5062149446 @default.
- W2912986113 hasAuthorship W2912986113A5067908401 @default.
- W2912986113 hasAuthorship W2912986113A5089664025 @default.
- W2912986113 hasConcept C104317684 @default.
- W2912986113 hasConcept C127561419 @default.
- W2912986113 hasConcept C203014093 @default.
- W2912986113 hasConcept C54355233 @default.