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- W2912987095 abstract "Vancomycin analogues bearing an A-ring trimethylammonium salt modification were synthesized and their antimicrobial activity against vancomycin-resistant Enterococci (VRE) was evaluated. The modification increased antimicrobial potency and provided the capability to induce bacteria cell membrane permeabilization, but both properties were weaker than that found with our earlier reported similar C-terminus modification. The results provide further insights on the additive effect and generalizability of the structural and site-specific nature of a peripheral quaternary trimethylammonium salt modification of vancomycin." @default.
- W2912987095 created "2019-02-21" @default.
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- W2912987095 date "2019-06-01" @default.
- W2912987095 modified "2023-09-26" @default.
- W2912987095 title "Exploration of the site-specific nature and generalizability of a trimethylammonium salt modification on vancomycin: A-ring derivatives" @default.
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- W2912987095 doi "https://doi.org/10.1016/j.tet.2019.02.008" @default.
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